| 引用本文: | 高捷,常忆凌,单伟光.蛇床子素水凝胶栓的研制及含量测定[J].中国现代应用药学,2012,29(11):1006-1009. |
| GAO Jie,CHANG Yiling,SHAN Weiguang.Preparation and Content Determination of Osthole Aquogel Suppository[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(11):1006-1009. |
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| 摘要: |
| 目的 制备蛇床子素水凝胶栓，并建立其含量测定方法。方法 用正交设计法筛选得到最佳处方，采用HPLC测定蛇床子素水凝胶栓的含量。结果 蛇床子素水凝胶栓剂的最佳处方为：海藻酸钠0.4 g、吐温-80 2.4 g、单硬脂酸甘油酯1.2 g、卡波姆0.4 g。该处方条件下，3批栓剂样品的蛇床子素含量分别为每颗13.23，13.95，13.19 mg。结论 该处方设计合理，含量测定方法操作简便、快速准确。 |
| 关键词: 卡波姆 水凝胶 栓剂 正交设计 含量测定 |
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| Preparation and Content Determination of Osthole Aquogel Suppository |
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GAO Jie1, CHANG Yiling1, SHAN Weiguang2
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1.Zhejiang Pharmaceutical College, Ningbo 315100, China;2.Zhejiang University of Technology, Hangzhou 310014, China
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| Abstract: |
| OBJECTIVE To preparation of osthole aquogel suppository and to establish its assay method. METHODS The optimal formula was optimized by orthogonal experiment and the content of osthole aquogel suppository was determined by HPLC. RESULTS The optimized formula was as follows: sodium alginate 0.4 g, Tween-80 2.4 g, glycerol monostearate 1.2 g, carbomer 0.4 g. With the optimal formula, the content of osthole in 3 batches of suppositories were 13.23, 13.95, 13.19 mg, respectively. CONCLUSION The design of the formula is reasonable, the method for assaying is simple, fast and accurate. |
| Key words: carbomer aquogel suppository orthogonal design content dertermination |
