| 引用本文: | 臧凯宏,杜丽东,刘晓梅,马骏,任远.冬凌草甲素片对醋酸诱导的小鼠溃疡性结肠炎的治疗作用[J].中国现代应用药学,2012,29(9):781-785. |
| ZANG Kaihong,DU Lidong,LIU Xiaomei,MA Jun,REN Yuan.Therapeutic Effect of Oridonin Tablet on Acetic Acid-induced Ulcerative Colitis in Mice[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(9):781-785. |
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| 摘要: |
| 目的 考察冬凌草甲素片口服给药对醋酸诱导的小鼠溃疡性结肠炎的治疗作用。方法 醋酸诱导的溃疡性结肠炎小鼠分别给予不同剂量的冬凌草甲素片灌胃给药，给药7 d后，考察冬凌草甲素片对溃疡性结肠炎小鼠病变活动(体质量、便潜血及粪便性状)的影响，以及对结肠病理组织学变化，结肠髓过氧化物酶活性及胸腺和脾脏指数的影响。结果 冬凌草甲素片口服给药可剂量依赖性的降低结肠炎小鼠的病变活动、减轻结肠炎症、降低髓过氧化物酶活性，改善免疫器官脏器指数，以冬凌草甲素片高剂量给药组的作用更为显著。结论 高剂量冬凌草甲素片口服给药对醋酸诱导的小鼠溃疡性结肠炎具有治疗作用，其机制可能与冬凌草甲素的抗炎和免疫调节作用有关。 |
| 关键词: 冬凌草甲素 溃疡性结肠炎 治疗作用 小鼠 |
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| Therapeutic Effect of Oridonin Tablet on Acetic Acid-induced Ulcerative Colitis in Mice |
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ZANG Kaihong1,2, DU Lidong1,2, LIU Xiaomei3, MA Jun1,2, REN Yuan1,2
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1.Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China;2.Gansu Key Laboratory of Phamacology and Toxicology of Traditional Chinese Medinice, Lanzhou 730000, China;3.Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China
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| Abstract: |
| OBJECTIVE To investigate the therapeutic effect of Oridonin tablet on acetic acid-induced ulcerative colitis in mice. METHODS Oridonin tablets at different dosages were administered orally to acetic acid-induced colitis mice. After 7 days of treatment, the effects of Oridonin tablet on disease activity (i.e. body weight, stool blood, and stool consistency), colonic macroscopic and histological score, myleoperoxidase activity, and thymic and splenic indexes were evaluated in acetic acid-induced ulcerative colitis in mice. RESULTS Oridonin tablet treatment dose-dependently reduced the disease activity, attenuated colonic inflammation and myleoperoxidase activity, and improved the thymic and splenic indexes in acetic acid-induced ulcerative colitis in mice, especially in high dose of Oridonin tablet treated group. CONCLUSION High dose of Oridonin tablet treatment shows therapeutic effect on acetic acid-induced ulcerative colitis in mice, the underlying mechanism may have close correlation with its anti-inflammatory and immune regulatory effects. |
| Key words: oridonin ulcerative colitis therapeutic effect mice |
