筋骨草中总环烯醚萜苷的提取动力学研究

王维; 戴晓燕

引用本文:	王维,戴晓燕.筋骨草中总环烯醚萜苷的提取动力学研究[J].中国现代应用药学,2012,29(9):808-811.
	WANG Wei,DAI Xiaoyan.Kinetics on Extraction of Iridoid Glycosides from Ajuga Decumbens[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(9):808-811.

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筋骨草中总环烯醚萜苷的提取动力学研究
王维¹, 戴晓燕²
1.杭州市第三人民医院药剂科，杭州 310009;2.浙江中医药大学，杭州 310053

摘要:

目的研究筋骨草中总环烯醚萜苷提取过程的动力学机制。方法采用比色法，测定不同提取温度条件下筋骨草水提液中总环烯醚萜苷的含量。以Fick扩散定律为基础，建立其提取过程的动力学方程，并由此推算出提取的速率常数、活化能、半衰期等动力学函数值。结果所得的动力学模型能较好地描述筋骨草中总环烯醚萜苷提取的动态过程，其表观活化能为45.18 kJ·mol^-1。结论筋骨草中总环烯醚萜苷提取过程的动力学符合一级动力学方程特征。

关键词: 筋骨草总环烯醚萜苷提取动力学

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Kinetics on Extraction of Iridoid Glycosides from Ajuga Decumbens

WANG Wei¹, DAI Xiaoyan²

1.Department of Pharmacy, Hangzhou Third People's Hospital, Hangzhou 310009, China;2.Zhejiang Chinese Medicine University, Hangzhou 310053, China

Abstract:

OBJECTIVES To investigate kinetic characteristics of extraction process of iridoid glycosides from Ajuga decumbens. METHODS Colorimetric method was used to determine the contents of iridoid glycosides by water extraction. The Fick's law of diffusion was used to establish the kinetics equation of iridoid glycosides extracting parameters. The extraction was analyzed to obtain kinetics parameters, such as K (rate constant), E_a (activation energy), and t_1/2 (half life). RESULTS The experiments for extracting iridoid glycosides from A. decumbens were studied under different conditions to evaluate the kinetic equation based on Fick's first law of diffusion. Experimental data could match the kinetic equation with its apparent activation energy as 45.18 kJ·mol^-1. CONCLUSION The results show that the kinetics on the extraction of iridoid glycosides match the first-order rate equation.

Key words: Ajuga decumbens iridoid glycosides extraction kinetics