| 引用本文: | 刘秀英,郑世君,王玉梅,陈建征,张桂森.GC测定盐酸氟西汀中二氯甲烷残留量[J].中国现代应用药学,2012,29(9):849-851. |
| LIU Xiuying,ZHENG Shijun,WANG Yumei,CHEN Jianzheng,ZHANG Guisen.Determination of Residual Dichloromethan in Fluoxetine by GC[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(9):849-851. |
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| 摘要: |
| 目的 采用气相色谱法检测盐酸氟西汀中的二氯甲烷残留量。方法 色谱柱：DB-624毛细管柱(30 m×0.53 mm)；载气：高纯氮气，0.05 MPa；检测器：ECD；进样口温度：150 ℃；检测器温度：300 ℃；柱温为程序升温；进样量：1 μL；分流比：1∶20。结果 二氯甲烷在5.96~71.55 μg·mL-1内，峰面积和浓度之间呈良好的线性关系(r=0.999 6)，3批样品中的二氯甲烷残留量均符合规定(<0.06%)。结论 该方法操作简便，精密度好，准确性高，可用于检测盐酸氟西汀中二氯甲烷残留量。 |
| 关键词: 气相色谱法 盐酸氟西汀 二氯甲烷 |
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| Determination of Residual Dichloromethan in Fluoxetine by GC |
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LIU Xiuying, ZHENG Shijun, WANG Yumei, CHEN Jianzheng, ZHANG Guisen
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Nhwa Pharma Corporation, Xuzhou 221007, China
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| Abstract: |
| OBJECTIVE To detect the residue dichloromethane in fluoxetine by gas chromatography(GC). METHODS Residue dichloromethane in fluoxetine was detected by GC with DB-624 column(30 m×0.53 mm), ECD detector and nitrogen as carrier gas(0.05 MPa). Injector and detector temperatures was set at 150 and 300 ℃ respectively. Column temperature was programmed set. Injection volume was 1 μL and the split ratio was 1∶20. RESULTS Dichloromethane showed a good linear relationship in the range of 5.96~71.55 μg·mL-1(r=0.999 6), the residue dichloromethane in three batches of samples coincided with the requirements(<0.06%). CONCLUSION Gas chromatography(GC) is simple, accurate, sensitive. It can be used for the determination of dichloromethane in fluoxetine. |
| Key words: GC fluoxetine dichloromethane |
