| 引用本文: | 胡士高,孙备.口服固体制剂原辅料相容性研究进展[J].中国现代应用药学,2012,29(9):789-793. |
| HU Shigao,SUN Bei.Progress of Drug-excipients Compatibility in Oral Solid Dosage Forms[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(9):789-793. |
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| 摘要: |
| 对近年来国内外在原辅料相容性方面的研究进行综述，以便于制剂工作者更好地进行处方设计。笔者首先分析了口服固体制剂原辅料发生不相容的原因，随后对各种原辅料相互作用进行了深入的阐述，并列举了近年来研究的成果；随后对影响原辅料相互作用的外界因素进行了分析和列举；最后对近年来采用的原辅料相容性研究手段进行了综述，为今后更好地开展此类研究提供参考。 |
| 关键词: 相容性 研究进展 原辅料 口服固体制剂 |
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| Progress of Drug-excipients Compatibility in Oral Solid Dosage Forms |
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HU Shigao1, SUN Bei2
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1.Anhui Center for Drug Evaluation & Certification, Hefei 230051, China;2.Anhui Provincial Institute of Materia Medica, Hefei 230022, China
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| Abstract: |
| To summarize the recently researches of drug-excipients compatibility, in order to help the pharmaceutical dosage formula design. The reasons of the incompatibility of drug-excipients in oral solid dosage forms were analysed at first, then the interactions of drug-excipients were disscused deeply, some research achievements were examplized. The extra-factors which influence the drug-excipients compatibility were disccused. The advanced research methods were summarized to help researches in this field. |
| Key words: compatibility progress drug-excipients oral solid dosage forms |
