| 摘要: |
| 目的 综述了乳糖在干粉吸入剂(dry powder inhalers，DPI)中的应用，为DPI的研究和开发提供思路。方法 查阅国内外相关文献，综述了载体乳糖(coarse carrier)的不同性质及加入微粉化乳糖(fine particles)对DPI肺部沉积的影响。结果 DPI中的药物经微粉化后，其雾化性能下降。乳糖应用于DPI中的研究分析表明，乳糖可以有效改善DPI中药物的雾化性能，从而提高药物在肺部的沉积效率，发挥最佳药效。结论 加入不同性质的载体乳糖和微粉化乳糖可以有效改善药物在肺部的沉积效率。 |
| 关键词: 乳糖 载体 微粉化乳糖 干粉吸入剂 |
| DOI： |
| 分类号: |
| 基金项目:江苏省中医药领军人才项目(LJ200913 ) |
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| Application of Lactose in Dry Powder Inhaler |
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CAO Wei, CHEN Yan, ZHANG Zhenhai1,2
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1.Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China;2.Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
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| Abstract: |
| OBJECTIVE The application of lactose in dry powder inhalers (DPI) was reviewed and the ideas for research and development of DPI were provided. METHODS After looking up the related references published recently, home and abroad, the influenced of coarse carrier properties and added fine particles on pulmonary deposition of DPI were mainly summarized. RESULTS Aerosol performance of drugs in DPI is decreased after micronization. Research shows that the aerosol performance of drugs could be effectively improved by adding lactose, thereby the efficiency of drugs deposition in the lung is enhanced and the best potency is achieved. CONCLUSION The deposition of drugs in the lung could be effectively improved by adding coarse carrier with different properties and fine particles. |
| Key words: lactose coarse carrier fine particles dry powder inhaler |
