| 引用本文: | 熊雪丰，何三民，石森林.新型胃滞留给药系统的研究进展[J].中国现代应用药学,2011,28(11):988-994. |
| XIONG Xuefeng, HE Sanmin, SHI Senlin.Progress in the Study of the Novel Gastroretentive Drug Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(11):988-994. |
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| 摘要: |
| 目的 介绍新型胃滞留给药系统近年来的研究进展，为研究开发胃滞留制剂提供参考。方法 通过查阅近年国内外相关文献，进行分析、整理和归纳。结果 胃滞留给药系统能改善药物吸收，有效提高生物利用度，其中，以漂浮型、生物黏附型、膨胀型等三类胃滞留给药系统的研究较多。结论 随着对胃滞留给药系统的深入研究，以及新型药用高分子材料的开发和制剂新技术的发展，胃滞留制剂具有广阔的应用前景。 |
| 关键词: 胃滞留 新剂型 缓控释 滞留时间 |
| DOI： |
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| 基金项目:浙江省中医药科技计划项目(2009CA103) |
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| Progress in the Study of the Novel Gastroretentive Drug Delivery System |
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XIONG Xuefeng, HE Sanmin, SHI Senlin1,2
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1.Zhejiang Chinese Medical University, Hangzhou 310053, China;2.Jinhua Center Hospital, Jinhua 321000, China
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| Abstract: |
| OBJECTIVE To introduce the progress of the novel gastroretentive drug delivery system, and provide the reference for study on gastroretentive dosage form. METHODS Look up the related references published in home and abroad in recent years, then analyze, arrange and sum up them. RESULTS The novel gastroretentive drug delivery system can increase the absorption and bioavailability of drugs, and the researches on floating drug delivery system, mucoadhesive drug delivery system and expandable drug delivery system are widely studied. CONCLUSION With the further study on gastroretentive drug delivery systems and the development of novel high polymer materials and new technology, this formulation will has wider application prospects. |
| Key words: gastroretentive novel dosage form sustained-controlled release residence time |
