| 摘要: |
| 目的 研究淫羊藿主要成分朝藿定C和双藿苷A对实验大鼠炎性病变的影响。方法 采用蛋清致大鼠足肿胀炎症法测定主要成分双藿苷A和朝藿定C对大鼠足肿胀的影响，计算肿胀度，并与蒸馏水组、吲哚美辛组进行比较。结果 主要成分朝藿定C和双藿苷A与蒸馏水组进行比较，两者均能明显减少蛋清所致大鼠足肿胀(P<0.01)；与吲哚美辛组比较，低剂量朝藿定C组差异无统计学意义，而高剂量朝藿定C组差异则有统计学意义。结论 朝藿定C和双藿苷A具有抗炎作用。 |
| 关键词: 巫山淫羊藿 朝藿定C 双藿苷A 抗炎作用 |
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| 基金项目:陕西省教育厅项目(09JK319)；陕西省教育厅专项资助项目(2010JS098)；安康学院高层次人才启动经费资助项目(AYQDZR200801) |
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| Antiinflammatory Effect of Epimedin C and Diphylloside A of Epimedium Wushanense T. S. Ying.s |
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1.安康学院化学化工系，陕西 安康 725000；2.西北大学陕西省生物医药重点实验室，西安 7100691,2
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1.Department of Chemistry and Engineering, Ankang University, Ankang 725000, China;2.Biology and Medicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 710069, China
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| Abstract: |
| OBJECTIVE To study the antiinflammatory effect of epimedin C and diphylloside A of Epimedium wushanense T. S. Ying.s on rats. METHODS Effect of epimedin C and diphylloside A on swelling foot of rats induced by egg was assayed, degree of swelling was calculated, and compared with distilled water or indomethacin. RESULTS Swelling of the rats foot induced by egg was reduced by epimedin C and diphylloside A, and there was significant difference, compared with distilled water (P<0.05); and there was significant difference of epimedin C in high dosage, compared with indomethacin, but there was no significant difference of epimedin C in low dosage. CONCLUSION Epimedin C and diphylloside A have antiinflammation effect. |
| Key words: Epimedium wushanense epimedin C diphylloside A antiinflammation |
