| 引用本文: | 陶华明，朱全红，徐满才.ADS-7多功能吸附树脂制备高纯度丹酚酸B的应用研究[J].中国现代应用药学,2012,29(2):113-116. |
| TAO Huaming, ZHU Quanhong, XU Mancai.Preparation of High-purity Salvianolic Acid B from Salvia Miltiorrhiza with Multifunctional Resin ADS-7[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(2):113-116. |
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| 摘要: |
| 目的 探讨ADS-7多功能吸附树脂对丹参中丹酚酸B的分离纯化方法。方法 以丹酚酸B的含量及洗脱率为指标，通过动态吸附试验考察ADS-7树脂的吸附性能。结果 ADS-7树脂对丹参中丹酚酸B具有较高的吸附选择性，吸附量为95.7 mg·g-1(干树脂)，甲酸/50%乙醇(10∶90)作为洗脱剂，丹酚酸B的纯度高达87.2%。结论 ADS-7树脂用于丹参中丹酚酸B的分离纯化简单高效。 |
| 关键词: 丹参 丹酚酸B ADS-7树脂 纯化 |
| DOI： |
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| 基金项目:国家自然科学基金(基金号：20474015) |
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| Preparation of High-purity Salvianolic Acid B from Salvia Miltiorrhiza with Multifunctional Resin ADS-7 |
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TAO Huaming, ZHU Quanhong, XU Mancai1,2
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1.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;2.College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China
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| Abstract: |
| OBJECTIVE To study the method for separating and purifying the salvianolic acid B from Salvia miltiorrhiza with multifunctional resin ADS-7. METHODS By using the content and elution rate of salvianolic acid B as indexes, the dynamic adsorption tests were employed to investigate adsorption capability of ADS-7 resin. RESULTS ADS-7 resin could be used to produce the salvianolic acid B with high quality. The dynamic adsorption capacity was 95.7 mg·g-1 (dry resin), the purity of the salvianolic acid B was 87.2% when eluted with formic acid/50% ethanol (10∶90). CONCLUSION It is a simple and efficient method to separate the salvianolic acid B from Salvia miltiorrhiza with ADS-7 resin. |
| Key words: Salvia miltiorrhiza salvianolic acid B ADS-7 resin purification |
