| 摘要: |
| 目的 研究介孔分子筛MCM-41对阿司匹林的缓释作用。方法 以正硅酸乙酯为硅源，CTAB为模板剂，于室温、酸性条件下合成介孔分子筛MCM-41。采用浸渍法将阿司匹林装载在MCM-41孔道中，考察分子筛对阿司匹林的最大载药量。利用XRD、氮吸附、红外光谱法对组装前后的分子筛进行表征，并研究组装于分子筛上的阿司匹林在磷酸盐缓冲溶液中的释放情况。结果 MCM-41对阿司匹林的最大载药量达0.34 g·g-1。组装体中的阿司匹林8 h和31 h时累积释放67.6%和90.2%。结论 介孔分子筛MCM-41对阿司匹林具有明显的缓释作用，介孔分子筛可作为一种新型药物缓释材料。 |
| 关键词: 介孔分子筛MCM-41 阿司匹林 缓释作用 |
| DOI： |
| 分类号: |
| 基金项目:山东省卫生厅资助课题(2007HW036) |
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| Effects of Mesoporous Molecular Sieve MCM-41 on the Sustained Release of Aspirin |
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DING Lin, WANG Huiyun
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School of Pharmacy, Jining Medical University, Rizhao 276826, China
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| Abstract: |
| OBJECTIVE To study the aspirin sustained release based on the matrix of mesoporous molecular sieve MCM-41. METHODS Mesoporous molecular sieve MCM-41 was synthesized using TEOS as silicon source and CTAB as templates at room temperature and under acidic conditions. Aspirin was loaded into MCM-41 by immersion method. The obtained aspirin-MCM-41 assembly was characterized by IR, XRD and N2-adsorption method. The maximum aspirin loading was determined. Finally the extended release of aspirin in assembly was demonstrated by in vitro release study. RESULTS The maximum aspirin loading into MCM-41 was 0.34 g·g-1. 67.6% and 90.2% of aspirin was released from the assembly at 8 h and 31 h, respectively. CONCLUSION The result showed that the effect of slow release for aspirin was achieved by using the mesoporous molecular sieve MCM-41 as matrix, indicating a potential application of mesoporous molecular sieve in the sustained drug release system. |
| Key words: mesoporous moleculr sieve MCM-41 aspirin sustained release |
