| 引用本文: | 祝典凡,周良良,姜婕,陈振华.复合型结肠靶向给药系统的研究进展[J].中国现代应用药学,2022,39(5):705-709. |
| ZHU Dianfan,ZHOU Liangliang,JIANG Jie,CHEN Zhenhua.Research Progress of Complex Oral Colon-specific Drug Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(5):705-709. |
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| 摘要: |
| 口服结肠靶向给药系统(oral colon-specific drug delivery system，OCDDS)具有明显的靶向定位性、可提高局部药物浓度、直接作用于病变部位、降低药物剂量、减少不良反应等优点，常用于提高炎症性肠病和结肠癌的治疗效果。复合型OCDDS较单一型OCDDS具有靶向性好、局部刺激小和药效高等优势，近年来备受研究者们的关注。本文通过对复合型OCDDS在结肠性疾病治疗中的应用进行综述，以期为OCDDS的深入研究和结肠性疾病的临床治疗提供参考。 |
| 关键词: 炎症性肠病 结肠癌 复合型口服结肠靶向给药系统 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.05.023 |
| 分类号:R943 |
| 基金项目:国家自然科学基金项目（81703716）；江西省自然科学基金项目（20202BABL206151）；江西省级研究生创新专项资金资助项目（YC2020-S577）；大学生创新训练计划项目（20201404121） |
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| Research Progress of Complex Oral Colon-specific Drug Delivery System |
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ZHU Dianfan, ZHOU Liangliang, JIANG Jie, CHEN Zhenhua
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School of Pharmacy, Jiangxi Science and Technology Normal University, Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, Nanchang 330013, China
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| Abstract: |
| Oral colon-specific drug delivery system(OCDDS) has many advantages, such as targeting localization, increasing drug concentration at target position, acting on lesion site directly and reducing the effective dose and adverse reaction of drugs. It is often used to improve the therapeutic effect of inflammatory bowel disease and colon cancer. Compared with single OCDDS, complex OCDDS has the advantage of better targeting, less local stimulation and high efficacy, which has attracted much attention of researchers in recent years. The applications of complex OCDDS in the treatment of colonic diseases were reviewed in this manuscript, in order to provide reference for the further study of OCDDS and the clinical treatment of colon diseases. |
| Key words: inflammatory bowel disease colon cancer complex OCDDS |
