| 引用本文: | 芮雪琳,李嘉诚,张孟孟,杨晔,徐莉,江倩倩,尹登科.排脓散对葡聚糖硫酸钠诱导结肠炎小鼠的治疗作用[J].中国现代应用药学,2021,38(23):2940-2944. |
| RUI Xuelin,LI Jiacheng,ZHANG Mengmeng,YANG Ye,XU Li,JIANG Qianqian,YIN Dengke.Therapeutic Effect of Painong Powder on Dextran Sodium Sulfate-induced Colitis Mice[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(23):2940-2944. |
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| 排脓散对葡聚糖硫酸钠诱导结肠炎小鼠的治疗作用 |
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芮雪琳1, 李嘉诚1, 张孟孟1, 杨晔1,2, 徐莉1, 江倩倩1, 尹登科1,2,3
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1.安徽中医药大学药学院, 合肥 230012;2.新安医学教育部重点实验室, 合肥 230012;3.现代中药研究与开发安徽省重点实验室, 合肥 230012
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| 摘要: |
| 目的 考察排脓散对结肠炎小鼠的治疗作用，为其临床使用提供依据。方法 采用♂BALB/c小鼠，设置正常组、模型组、柳氮磺吡啶组和排脓散高、中、低剂量组，在日常饮水中给予3%葡聚糖硫酸钠（dextran sodium sulfate，DSS）构建结肠炎模型，通过测定小鼠体质量、疾病活动指数（disease activity index，DAI）评分情况、结肠长度和结肠炎性因子表达水平，研究排脓散对小鼠结肠炎的治疗作用。结果 与模型组相比，排脓散各剂量组和柳氮磺吡啶组的小鼠体质量下降均有不同程度的缓解，DAI评分均显著降低（P<0.05），并部分恢复结肠长度。排脓散可以减少结肠部位IL-1β、TNF-α和IL-6表达，提高IL-10表达。结论 排脓散可以减轻DSS诱导的结肠炎症状，改善炎症相关因子表达。 |
| 关键词: 排脓散 结肠炎 炎性因子 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.23.005 |
| 分类号:R285.5 |
| 基金项目:国家自然科学基金项目（81874348）；新安医学教育部重点实验室开放课题（2020xayx11）；安徽中医药大学探索性科研项目（2017HXTS42） |
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| Therapeutic Effect of Painong Powder on Dextran Sodium Sulfate-induced Colitis Mice |
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RUI Xuelin1, LI Jiacheng1, ZHANG Mengmeng1, YANG Ye1,2, XU Li1, JIANG Qianqian1, YIN Dengke1,2,3
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1.School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;2.Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei 230012, China;3.Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China
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| Abstract: |
| OBJECTIVE To investigate the therapeutic effect of Painong powder on colitis mice and to provide evidence for its clinical use. METHODS Male BALB/c mice were used to set the blank group, model group, sulfasalazine group and Painong powder high, medium and low doses group. The 3% dextran sodium sulfate(DSS) was administered in the daily drinking water to construct a colitis model, and to study the therapeutic effect of Painong powder on colitis model by measuring the body weight, disease activity index(DAI) score, colon length, and inflammatory factor expression. RESULTS Compared with the model group, the weight loss of the mice in three dose of Painong powder group and the sulfasalazine treatment group was relieved in different degrees, the DAI score was significantly reduced(P<0.05), and the colon length was partially restored. Painong powder could reduce the expression of IL-1β, TNF-α and IL-6 in the colon and increase the expression of IL-10. CONCLUSION Painong powder alleviates the symptoms of DSS-induced colitis and improves the expression of inflammation-related factors. |
| Key words: Painong powder colitis inflammatory factor |
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