新型冠状病毒肺炎患者实验室指标改变发生率的meta分析

张宇宇; 黄芸; 叶子奇; 方崇波; 周华<sup>*</sup>

引用本文:	张宇宇,黄芸,叶子奇,方崇波,周华.新型冠状病毒肺炎患者实验室指标改变发生率的meta分析[J].中国现代应用药学,2022,39(7):946-951.
	ZHANG Yuyu,HUANG Yun,YE Ziqi,FANG Chongbo,ZHOU Hua.Meta-analysis of Incidence of Laboratory Changes in Patients with COVID-19[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(7):946-951.

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新型冠状病毒肺炎患者实验室指标改变发生率的meta分析
张宇宇¹, 黄芸¹, 叶子奇², 方崇波¹, 周华¹
1.宁波市医疗中心李惠利医院临床药学部, 浙江宁波 315000;2.浙江大学医学院附属第一医院临床药学部, 杭州 310003

摘要:

目的通过分析新型冠状病毒肺炎患者包括白细胞计数等实验室指标改变的发生率情况，为该疾病的识别及诊治提供参考。方法系统检索Pubmed数据库、Embase数据库、Cochrane图书馆及中国知网、万方和维普数据库国内外新型冠状病毒肺炎临床特征和流行病学特征的相关临床研究，采用Stata 12.0进行单样本率的meta分析。结果共纳入15项回顾性研究。Meta分析研究结果发现，研究存在异质性，新型冠状病毒肺炎患者实验室指标发生改变，其中白细胞计数正常或减少发生率为90%[95%CI(87%~93%)]，C反应蛋白(C-reactive protein，CRP)升高发生率为61%[95%CI(50%~ 73%)]，淋巴细胞计数减少发生率为43%[95%CI(28%~59%)]，降钙素原(procalcitonin，PCT)升高发生率为13%[95%CI (8%~18%)]，红细胞沉降率(erythrocyte sedimenta rate，ESR)升高发生率为74%[95%CI(61%~87%)]。结论新型冠状病毒肺炎患者发病时白细胞计数一般正常或减少，CRP和ESR可能升高。

关键词: 新型冠状病毒肺炎实验室指标 meta分析

DOI：10.13748/j.cnki.issn1007-7693.2022.07.014

分类号:R969.3

基金项目:浙江省自然科学基金项目（LY19H310007）；浙江省医药卫生科技计划项目（2019KY604）；浙江省药学会医院药学专项科研资助项目（2018ZYY36）

Meta-analysis of Incidence of Laboratory Changes in Patients with COVID-19

ZHANG Yuyu¹, HUANG Yun¹, YE Ziqi², FANG Chongbo¹, ZHOU Hua¹

1.Department of Pharmacy, Ningbo City Medical Treatment Center Lihuili Hospital, Ningbo 315000, China;2.Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

Abstract:

OBJECTIVE To provide reference of the identification and diagnosis of coronavirus disease 2019(COVID-19) by analyzing the incidence of changes in laboratory indexes including leukocyte count in patients with COVID-19. METHODS Databases of Medline, Embase, Cochrane library, CNKI, Wangfang and VIP were searched for study of clinical features and epidemiological features of COVID-19, Stata 12.0 were performed to conduct single sample rate meta-analysis. RESULTS A total of 15 studies contributed to the meta-analysis, revealing a large degree of inconsistency among the trials:the incidence of normal or decreased white blood cell count was 90%[95%CI(87%-93%)], the incidence of C-reactive protein(CRP) elevation was 61%[95%CI(50%-73%)], the incidence of decreased lymphocyte count was 43%[95%CI(28%-59%)], the incidence of procalcitonin(PCT) elevation was 13%[95%CI(8%-18%)], and the incidence of erythrocyte sedimenta rate(ESR) elevation was 74%[95%CI(61%-87%)]. CONCLUSION The white blood cell count is usually normal or decreased, CRP and ESR may increase among patients with COVID-19.

Key words: COVID-19 laboratory indexes meta analysis