| 引用本文: | 杜悦,张恕芳,牟燕,李妍.基因多态性对肾移植术后他克莫司药动学影响的研究进展[J].中国现代应用药学,2021,38(21):2741-2747. |
| DU Yue,ZHANG Shufang,MU Yan,LI Yan.Advances in the Effects of Gene Polymorphisms on Pharmacokinetics of Tacrolimus After Kidney Transplantation[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(21):2741-2747. |
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| 摘要: |
| 肾移植是终末期肾脏疾病有效的治疗手段，为降低肾移植术后排斥反应风险，患者术后需长期服用免疫抑制剂，他克莫司为目前最广泛应用的钙调蛋白类免疫抑制剂。然而，在临床应用中，他克莫司表现出治疗窗窄、药动学个体差异大等特点。在影响其个体间差异的相关因素中，基因多态性是目前研究的热点之一。本文通过检索文献，就常见的基因多态性对他克莫司药动学的影响进行综述，旨在阐明特定基因型对他克莫司药动学的影响，为提高他克莫司个体化治疗水平提供参考。 |
| 关键词: 他克莫司 基因多态性 肾移植 药动学 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.21.018 |
| 分类号:R969.1 |
| 基金项目:国家重点研发项目精准专项医疗集成应用示范体系建设项目（2017YFC0910004）；济南市科技计划项目（201602171） |
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| Advances in the Effects of Gene Polymorphisms on Pharmacokinetics of Tacrolimus After Kidney Transplantation |
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DU Yue1, ZHANG Shufang1, MU Yan2, LI Yan2
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1.School of Pharmacy, Shandong First Medical University(Shandong Academy of Medical Sciences), Tai'an 271000, China;2.Clinical Pharmacy, the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital), Jinan 250014, China
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| Abstract: |
| Kidney transplantation is an effective treatment for end-stage renal disease. Patients need to take immunosuppressants for a long time to reduce the risk of rejection after transplantation. Although tacrolimus is the most widely used calmodulin immunosuppressant, it exhibits narrow therapeutic window and large individual differences in pharmacokinetics. Among the relevant factors affecting their individual differences, gene polymorphism is one of the hot spots in the recent researches. Through the literature retrieval, the article reviews the effects of familiar gene polymorphisms on the pharmacokinetics of tacrolimus, which aims to elucidate the influence of specific genes on the pharmacokinetics of tacrolimus and provide a reference for improving the level of individualized treatment of tacrolimus. |
| Key words: tacrolimus gene polymorphism kidney transplantation pharmacokinetics |
