川芎-天麻药对防治偏头痛的研究进展

常露露; 曾贵荣; 刘顶鼎<sup>*</sup>; 王静茹

引用本文:	常露露,曾贵荣,刘顶鼎,王静茹.川芎-天麻药对防治偏头痛的研究进展[J].中国现代应用药学,2021,38(10):1245-1250.
	CHANG Lulu,ZENG Guirong,LIU Dingding,WANG Jingru.Research Progress of Chuanxiong Rhizoma-Gastrodiae Rhizoma on Prevention and Treatment of Migraine[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(10):1245-1250.

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川芎-天麻药对防治偏头痛的研究进展
常露露¹, 曾贵荣², 刘顶鼎¹, 王静茹¹
1.贵州中医药大学, 贵阳 550025;2.湖南省药物安全评价研究中心/新药药效与安全性评价湖南省重点实验室, 长沙 410331

摘要:

偏头痛是临床常见的一种神经系统疾病，严重影响患者的工作与生活质量，因此，偏头痛的防治具有重要现实意义。研究表明川芎配伍天麻对偏头痛患者具有明显疗效，且现代药理研究发现其主要活性成分为阿魏酸、川芎嗪、洋川芎内酯类、天麻素、天麻苷元等，但其治疗偏头痛的物质基础及作用机制尚未阐明。本文通过综述国内外川芎-天麻药对相关文献报道，对其防治偏头痛的药效物质基础、作用机制进行归纳总结，为临床应用提供理论基础。

关键词: 川芎-天麻药对偏头痛药效物质基础作用机制

DOI：10.13748/j.cnki.issn1007-7693.2021.10.018

分类号:R285.6

基金项目:国家自然科学基金项目（81860844）；贵州省科技计划项目（黔科合基础[2016]1016，黔科合基础[2019]1038号）；贵州省教育厅青年科技人才成长项目（黔教合KY字[2016]185）；贵州省中医药、民族医药科学技术研究专项（QZYY-2016-001）；贵州中医药大学药效物质基础及作用机理研究中心（贵中医党办发[2019]70号）

Research Progress of Chuanxiong Rhizoma-Gastrodiae Rhizoma on Prevention and Treatment of Migraine

CHANG Lulu¹, ZENG Guirong², LIU Dingding¹, WANG Jingru¹

1.Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China;2.Hunan Provincial Research Center for Safety Evaluation of Drugs/Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410331, China

Abstract:

Migraine is a common clinical neurological disease, which seriously affects the quality of work and life of patients.Therefore, the prevention and treatment of migraine has important practical significance.Studies have shown that Chuanxiong Rhizoma-Gastrodiae Rhizoma has obvious effects on migraine patients, and modern pharmacological studies have found that its main active ingredients are ferulic acid, ligustrazine, ligustic acid lactones, gastrodin, gastrodigenin, etc.However, the material basis and mechanism of its treatment of migraine have not yet been elucidated.In this paper, by reviewing the relevant literature reports of Chuanxiong Rhizoma-Gastrodiae Rhizoma at home and abroad, it summarizes the effective material basis and mechanism of action for the prevention and treatment of migraine, providing a theoretical basis for clinical application.

Key words: Chuanxiong Rhizoma-Gastrodiae Rhizoma migraine medicinal material basis mechanism of action