| 引用本文: | 王双庆,左阿龙,郭建鹏.颊黏膜黏附膜的研究进展[J].中国现代应用药学,2022,39(1):134-140. |
| WANG Shuangqing,ZUO Along,GUO Jianpeng.Research Progress of Mucoadhesive Buccal Films[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(1):134-140. |
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| 摘要: |
| 近年来，大量研究证明颊黏膜黏附膜(mucoadhesive buccal films，MBFs)在全身或局部给药方面表现出高生物利用度，高顺应性，并具有制备难度低，能随时终止给药等优势，已成为最具产业化前景的颊黏膜给药系统。将药物溶解或分散于成膜材料中，通过多种制备工艺制备MBFs。MBFs机械性能直接影响其应用，但目前没有标准的表征方法。因此，本文从处方筛选、制备工艺和质量评价3个方面回顾了近年来MBFs的相关研究和上市制剂，总结了现阶段存在的问题，以期推动其研发和产业化进程。 |
| 关键词: 膜剂 口腔黏膜给药 黏附性 渗透性 药动学 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.01.023 |
| 分类号:R944.9 |
| 基金项目:国家自然科学基金项目(81660709) |
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| Research Progress of Mucoadhesive Buccal Films |
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WANG Shuangqing1, ZUO Along2, GUO Jianpeng1,2
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1.College of Pharmacy, Yanbian University, Yanji 133002, China;2.Yanbian Medical and Health Industry Test Base, Yanji 133002, China
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| Abstract: |
| In recent years, many studies have proved that mucoadhesive buccal films(MBFs) exhibit high bioavailability and high compliance in systemic or local drug delivery, and have the advantage of low preparation difficulty and have the ability to terminate drug delivery at any time. MBFs have become the most industrialized buccal mucosal drug delivery system. Drugs are dissolved or dispersed in film-former to prepare MBFs by various preparation processes. The mechanical properties of MBFs directly affect their application, but there is no standard characterization method at present. Therefore, this article reviews the MBFs that have been marketed and under research in recent years from the three aspects of prescription screening, preparation process and quality evaluation, and summarizes the existing problems at this stage, aiming to promote their development and the process of industrialization. |
| Key words: film oral mucosal administration adhesion permeability pharmacokinetic |
