| 引用本文: | 陈晨凯,王颖异,曹程,许惠琴,朱悦,段金廒,郭建明.年龄相关性黄斑变性的危险因素分析及对疾病动物模型构建的启示[J].中国现代应用药学,2021,38(15):1894-1900. |
| CHEN Chenkai,WANG Yingyi,CAO Cheng,XU Huiqin,ZHU Yue,DUAN Jin'ao,GUO Jianming.Risk Factors Analysis of Age-related Macular Degeneration and the Enlightenment to the Construction of Disease Animal Models[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(15):1894-1900. |
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| 年龄相关性黄斑变性的危险因素分析及对疾病动物模型构建的启示 |
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陈晨凯1, 王颖异1, 曹程1, 许惠琴2, 朱悦1, 段金廒1, 郭建明1
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1.南京中医药大学江苏省方剂高技术研究重点实验室, 江苏省中药资源产业化过程协同创新中心, 南京 210023;2.南京中医药大学江苏省中药药效与安全性评价重点实验室, 南京 210023
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| 摘要: |
| 年龄相关性黄斑变性（age-related macular degeneration，AMD）是一种影响视网膜黄斑区功能，引起中心视力进行性损伤的眼科疾病，是导致>60岁老年人视力受损的主要原因。随着中国社会老龄化进程的日益加深，AMD的患病率逐渐升高。AMD的具体发病机制尚不完全明确，构建合适的动物模型有助于阐明其相关病理机制。错综复杂的危险因素共同推动了AMD的发生发展，分析AMD的危险因素对动物模型的构建具有启示作用。 |
| 关键词: 年龄相关性黄斑变性 危险因素 临床分类 动物模型 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.15.017 |
| 分类号:R965.1 |
| 基金项目:国家自然科学基金项目（81773983） |
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| Risk Factors Analysis of Age-related Macular Degeneration and the Enlightenment to the Construction of Disease Animal Models |
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CHEN Chenkai1, WANG Yingyi1, CAO Cheng1, XU Huiqin2, ZHU Yue1, DUAN Jin'ao1, GUO Jianming1
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1.Nanjing University of Traditional Chinese Medicine, Jiangsu Key Laboratory of High Technology Research of TCM Formulae, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China;2.Nanjing University of Traditional Chinese Medicine, Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing 210023, China
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| Abstract: |
| Age-related macular degeneration(AMD) is an ophthalmic disease that affects the function of the macular area of the retina and causes progressive damage to the central vision. It is a leading cause of visual impairment to elderly people aged over 60 years. With the deepening of Chinese society's aging process, the prevalence of AMD is gradually increasing. The molecular mechanisms underlying the specific pathogenesis of AMD is poorly understood. The construction of a suitable animal model is critical to clarifying the pathogenesis of AMD. Intricate risk factors have jointly promoted the occurrence and development of AMD. Therefore, analysis of AMD risk factors may showed some light on its animal construction. |
| Key words: age-related macular degeneration risk factor clinical classification animal models |
