| 引用本文: | 樊丽雅,胡丽,张璐,石松利,郑春丽.苦杏仁苷自微乳的制备及理化性质的研究[J].中国现代应用药学,2022,39(4):475-479. |
| FAN Liya,HU Li,ZHANG Lu,SHI Songli,ZHENG Chunli.Study on Preparation and Physicochemical Properties of Amygdalin Self-microemulsion[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(4):475-479. |
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| 摘要: |
| 目的 制备苦杏仁苷自微乳,并进行初步质量评价研究。方法 通过平衡溶解度的测定和伪三元相图的绘制筛选苦杏仁苷的最佳处方,并对苦杏仁苷自微乳的粒径、多分散系数、稳定性进行评价。结果 苦杏仁苷自微乳的最优处方为Peceol/MCT (1︰ 1)-乳化剂OP-1,2-丙二醇=45%︰ 40%︰ 15%,载药量为6 mg·mL-1。所得苦杏仁苷自微乳平均粒径为(113.3±0.8) nm,多分散系数为(0.171±0.007),离心稳定性良好。结论 优选处方稳定可行,制备的苦杏仁苷自微乳粒径均匀,稳定性良好。 |
| 关键词: 苦杏仁苷 自微乳 伪三元相图 粒径 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.04.007 |
| 分类号:R283.6 |
| 基金项目: |
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| Study on Preparation and Physicochemical Properties of Amygdalin Self-microemulsion |
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FAN Liya1, HU Li2, ZHANG Lu1, SHI Songli1, ZHENG Chunli2
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1.School of Pharmacy, Baotou Medical College, Baotou 014040, China;2.School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
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| Abstract: |
| OBJECTIVE To prepare amygdalin self-microemulsion and to carry out preliminary quality evaluation. METHODS The best prescription of amygdalin was screened by the determination of equilibrium solubility and drawing of pseudo-ternary phase diagram. The particle size, polydispersity coefficient and stability of amygdalin self-microemulsion were evaluated. RESULTS The optimum formulation of amygdalin self-microemulsion was Peceol/MCT(1︰ 1)-emulsifier OP-1,2- propanediol=45%︰ 40%︰ 15% with drug loading of 6 mg·mL-1. The average particle size of amygdalin self-microemulsion was (113.3+0.8) nm, and the polydispersity coefficient was (0.171+0.007). The centrifugal stability of amygdalin self-microemulsion was good. CONCLUSION The optimized formulation is stable and feasible, and the prepared amygdalin self-microemulsion has uniform particle size and good stability. |
| Key words: amygdalin self-microemulsion pseudo-ternary phase diagram particle size |
