| 引用本文: | 陆姗姗,陈军,赵玉荣,徐怡冰,张曼琦,李浩榕.小茴香油微乳凝胶的制备及其体外透皮促渗行为研究[J].中国现代应用药学,2022,39(8):1067-1074. |
| LU Shanshan,CHEN Jun,ZHAO Yurong,XU Yibing,ZHANG Manqi,LI Haorong.Research on preparation of fennel oil microemulsion and promotion of transdermal permeability in vitro[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(8):1067-1074. |
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| 小茴香油微乳凝胶的制备及其体外透皮促渗行为研究 |
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陆姗姗1,2, 陈军2,3, 赵玉荣1, 徐怡冰1, 张曼琦1, 李浩榕1
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1.南京中医药大学翰林学院, 江苏 泰州 225300;2.南京中医药大学, 江苏省中医外用药开发与应用工程研究中心, 南京 210023;3.南京中医药大学, 江苏省中药资源产业化过程协同创新中心, 南京 210023
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| 摘要: |
| 目的 优化筛选出小茴香油微乳凝胶的最佳处方组成，并考察小茴香油微乳凝胶的体外透皮性能。方法 采用星点设计效应面法分别优化了微乳和微乳凝胶的处方，Franz扩散池法考察小茴香油微乳及其凝胶的体外透皮性能。结果 微乳最优处方为油相∶乳化剂和助乳化剂(吐温-80︰二乙二醇单乙基醚=2.5︰1)∶水=20︰27.6︰52.4，进一步制备得到了小茴香油微乳凝胶。小茴香油微乳的流动性及稳定性好，平均粒径为(42.03±0.9)nm、多分散性指数为(0.154±0.005)。小茴香油微乳凝胶均匀细腻，易涂展，有一定流动性，为乳白色半透明半固体凝胶。体外透皮性能结果表明小茴香油作为油相，制备成微乳和微乳凝胶，其体外透皮吸收量分别提高了3，4倍。结论 该研究为小茴香油的制剂技术奠定了基础，也为挥发油类药物的广泛应用提供了理论依据。 |
| 关键词: 小茴香油 微乳 微乳凝胶 星点设计-效应面法 经皮渗透 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.08.010 |
| 分类号:R943 |
| 基金项目:江苏省中药药效与安全性评价重点实验室资助项目(JKLPSE201808)；江苏省中药资源产业化过程协同创新中心重点项目(ZDXM-2020-1)；江苏省大学生创新创业训练计划一般项目(201913981002Y)；江苏省高等学校(自然科学)面上项目(21KJB360020) |
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| Research on preparation of fennel oil microemulsion and promotion of transdermal permeability in vitro |
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LU Shanshan1,2, CHEN Jun2,3, ZHAO Yurong1, XU Yibing1, ZHANG Manqi1, LI Haorong1
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1.Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, China;2.Nanjing University of Chinese Medicine, Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, Nanjing 210023, China;3.Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China
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| Abstract: |
| OBJECTIVE To optimize the optimal formulation composition of fennel oil microemulsion gel and to investigate its transdermal performance in vitro. METHODS The formulations of microemulsion and microemulsion gel were optimized by central composite design-response surface method, and the transdermal properties of the microemulsion and its gel were investigated by Franz diffusion pool method. RESULTS The optimal formula of microemulsion was oil phase:emulsifier and co-emulsifier(Tween-80:diethylene glycol monoethyl ether=2.5:1):water=20:27.6:52.4, and the microemulsion gel of fennel oil was prepared. The microemulsion of fennel oil had good fluidity and stability, the average particle size was (42.03±0.9)nm, and the polydispersion coefficient(PDI) was (0.154±0.005). The obtained microemulsion gel of fennel oil was uniform and delicate, easy to spread, and had a certain fluidity. It was an opalescent translucent semi-solid gel. The results of in vitro transdermal performance showed that microemulsion and microemulsion gel were prepared from fennel oil as oil phase, and the in vitro transdermal absorption of fennel oil was increased by 3 times and 4 times respectively. CONCLUSION This study lays a foundation for the preparation technology of fennel oil and provides a theoretical basis for the extensive application of volatile oil drugs. |
| Key words: fennel oil microemulsion microemulsion gel central composite design-response surface method transdermal permeability |
