| 引用本文: | 张雅军,吴先富,肖新月.差示扫描量热法测定磺胺类化学对照品的纯度[J].中国现代应用药学,2022,39(1):93-96. |
| ZHANG Yajun,WU Xianfu,XIAO Xinyue.Determination of the Purity of Sulfonamide Chemical Reference Materials by Differential Scanning Calorimetry[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(1):93-96. |
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| 摘要: |
| 目的 采用差示扫描量热法(differential scanning calorimetry，DSC)测定磺胺类化学对照品纯度。方法 采用优化DSC实验参数，载气流速50 mL·min-1，升温速率3 ℃·min-1，称样量1.3~2.0 mg，对7种磺胺类化学对照品进行纯度分析。结果 DSC测得磺胺噻唑纯度为99.9%，磺胺甲二唑为99.9%，磺胺甲氧嗪为99.8%，磺胺嘧啶为99.8%，磺胺甲噁唑为99.9%，磺胺多辛为99.5%和磺胺二甲嘧啶为99.9%，其结果与质量平衡法测定结果基本一致。结论 DSC简便、快捷、无需标准物质，为磺胺类化学对照品纯度测定提供了新的检测方法。 |
| 关键词: 差示扫描量热法 磺胺类 化学对照品 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.01.016 |
| 分类号:R917 |
| 基金项目: |
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| Determination of the Purity of Sulfonamide Chemical Reference Materials by Differential Scanning Calorimetry |
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ZHANG Yajun, WU Xianfu, XIAO Xinyue
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National Institutes for Food and Drug Control, Beijing 102629, China
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| Abstract: |
| OBJECTIVE To determine the purity of sulfonamide chemical reference substances by differential scanning calorimetry(DSC).METHODS The purity of 7 sulfonamide chemical reference substances was determined by optimizing DSC parameters, carrier gas flow rate was 50 mL·min-1, heating rate was 3 ℃·min-1 and weighing amount was 1.3-2.0 mg.RESULTS The purity determined by DSC were 99.9%(sulfathiazole), 99.9%(sulfamethizole), 99.8%(sulfamethoxypridazine), 99.8%(sulfadiazine), 99.9%(sulfamethoxazole), 99.7%(sulfadoxine), and 99.9%(sulfadimidine), respectively. The results of purity determination by DSC method were basically consistent with those by mass balance method.CONCLUSION DSC is a simple, rapid method, and does not need standard substance. It provides a new method for the purity determination of sulfonamide chemical reference substances. |
| Key words: differential scanning calorimetry sulfonamides chemical reference substances |
