| 引用本文: | 邱华,范春娇,苏翠丽,黄鹏,刘雪梅,李旺,蒙荫杰,何锦轶,毛德文,姚春.白花香莲解毒颗粒制备工艺研究[J].中国现代应用药学,2021,38(23):2921-2925. |
| QIU Hua,FAN Chunjiao,SU Cuili,HUANG Peng,LIU Xuemei,LI Wang,MENG Yinjie,HE Jinyi,MAO Dewen,YAO Chun.Study on the Preparation of Baihua Xianglian Jiedu Granules[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(23):2921-2925. |
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| 白花香莲解毒颗粒制备工艺研究 |
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邱华1,2, 范春娇3, 苏翠丽3, 黄鹏3, 刘雪梅3, 李旺3, 蒙荫杰3, 何锦轶3, 毛德文1, 姚春3
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1.广西中医药大学第一附属医院, 南宁 530023;2.广西医科大学附属肿瘤医院, 南宁 530021;3.广西中医药大学研究生院, 南宁 530001
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| 摘要: |
| 目的 优选出白花香莲解毒颗粒的最佳制备工艺。方法 以方中主药白花蛇舌草的特异性成分去乙酰车叶草酸甲酯及出膏率为考察指标，采用正交试验方法，优选出白花香莲解毒颗粒的最佳提取工艺。以成型率、溶化性、流动性等多项指标，对辅料、用量、工艺等条件进行考察，确定处方的成型工艺。结果 白花香莲解毒颗粒的最佳提取工艺为加10倍量水，提取2次，每次1.5 h；成型工艺为按稠膏：糊精=1：2比例加入糊精，以糊精稠膏混合物0.25%的阿司帕坦和0.25%甜菊素作为矫味剂，再加入45%乙醇作为润湿剂，混匀，过14目筛制粒，80℃鼓风干燥，整粒，即得。结论 优选出的提取工艺和成型工艺稳定可行，可为白花香莲解毒颗粒的制备与生产提供参考。 |
| 关键词: 白花香莲解毒颗粒 去乙酰车叶草酸甲酯 正交试验 制备工艺 壮药 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.23.002 |
| 分类号:R944.2+7 |
| 基金项目:国家自然科学基金项目（81860889）；中国博士后科学基金面上资助项目（2019M653312）；广西自然科学基金项目（2020JJA140308）；广西重点研发计划项目（桂科AB18126086）；广西中医药大学第一附属医院院内制剂课题（2017ZJ004） |
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| Study on the Preparation of Baihua Xianglian Jiedu Granules |
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QIU Hua1,2, FAN Chunjiao3, SU Cuili3, HUANG Peng3, LIU Xuemei3, LI Wang3, MENG Yinjie3, HE Jinyi3, MAO Dewen1, YAO Chun3
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1.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China;2.Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021;3.Graduate School of Guangxi University of Traditional Chinese Medicine, Nanning 530001, China
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| Abstract: |
| OBJECTIVE To optimize the preparation process of Baihua Xianglian Jiedu granules. METHODS The best extraction technology of Baihua Xianglian Jiedu granules was optimized by orthogonal test, with the specific component of deacetyl asperulosidic acid methyl ester of Hedyotis diffusa and the extract rate as the index. Based on the indexes of molding rate, solubility and fluidity, the conditions of excipients, dosage and technology were investigated to determine the molding technology of the prescription. RESULTS The best extraction process of Baihua Xianglian Jiedu granules was:add 10 times of water, extract twice, each time for 1.5 h; the molding process was add dextrin according to the proportion of thick paste:dextrin=1:2, take 0.25% aspatan and 0.25% stevia of the mixture of dextrin thick paste as the flavoring agent, then add 45% ethanol as the wetting agent, mix well, sift through 14 mesh, dry by air at 80℃, and complete the granules. CONCLUSION The optimized preparation technology is stable, simple and feasible, which can provide reference for the preparation and production of Baihua Xianglian Jiedu granules. |
| Key words: Baihua Xianglian Jiedu granule deacetyl asperulosidic acid methyl ester orthogonal test preparation process Zhuang medicine |
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