引用本文: | 何晓金,肖迪,石晓旭,冯雪梅,钟旭丽,张建民.某院2012-2023年儿童抗菌药物不良反应帕累托法分析[J].中国现代应用药学,2025,42(8):148-154. |
| HE xiaojin,XIAO di,SHI xiaoxu,FENG xuemei,ZHONG xuli,ZHANG jianmin.Pareto analysis of adverse drug reactions induced by antibacterial drugs in Children in a Hospital from 2012 to 2023[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(8):148-154. |
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某院2012-2023年儿童抗菌药物不良反应帕累托法分析 |
何晓金,肖迪,石晓旭,冯雪梅,钟旭丽,张建民
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首都儿科研究所附属儿童医院
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摘要: |
目的 分析本院儿童抗菌药物不良反应(ADR)发生规律和特点,为儿童安全用药提供参考。方法 收集本院2012年5月到2023年7月上报至国家药品不良反应监测系统的抗菌药物ADR报告236例,对患者的性别、年龄、给药途径、药品类别、累及系统/器官及临床表现、ADR发生时间、转归及上报人员进行分类,应用帕累托图分析。结果 236例ADR报告中,女性94例(39.83%),男性142例(60.17%)。年龄段分布以学龄期(29.24%)、幼儿期(25.85%)和学龄前期(23.31%)为主。静脉滴注是引发ADR的主要给药途径,占比(86.86%)。大环内酯类(21.54%)、糖肽类(15.85%)、头孢菌素类(15.04%)抗菌药物引发的ADR居多。抗菌药物累及最多的系统/器官是皮肤及附件,高达103例(42.21%)。ADR主要发生在用药后1天内以及用药后1-2d。上报人员中,药师上报216例,医师上报17例,护士上报3例。绝大多数ADR经处理后好转或痊愈。结论 儿童应用抗菌药物应全面考虑ADR,加强监护,确保临床用药安全。 |
关键词: 儿童 抗菌药物 药物不良反应 帕累托法 |
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基金项目:首都儿科研究所临床培育专项项目 |
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Pareto analysis of adverse drug reactions induced by antibacterial drugs in Children in a Hospital from 2012 to 2023 |
HE xiaojin1,2,3, XIAO di1,2,3, SHI xiaoxu1,2,3, FENG xuemei1,2,3, ZHONG xuli1,2,3, ZHANG jianmin1,2,3
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1.Children'2.'3.s Hospital affiliated to Capital Institute of Pediatrics
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Abstract: |
Objective To analyze the regularity and the characteristics of adverse drug reactions induced by antibacterial drugs in children so as to provide reference for safe clinical drug use in children.Methods A total of 236 reports of ADR induced by antibacterial drugs in children submitted by our hospital to the National ADR Monitoring Center between May 2012 to July 2023 were analyzed retrospectively.? the gender, age, route of administration, drug category, system/organ involved and clinical manifestations, ADR occurrence time, outcome and reporting personnel were classified,and analyzed by Pareto principle.Results Among 236 ADR reports, 94 cases (39.83%) were female and 142 cases (60.17%) were male. The age distribution were mainly school age (29.24%), early childhood (25.85%) and pre-school age (23.31%). Most of the cases of ADR were induced by intravenous injection, accounting for 86.86%. Macrolides (21.54%), glycopeptides (15.85%) and cephalosporins (15.04%) caused the majority of ADR. The injury to the skin and adnexa was the most common ADR, which accounted for 103 cases (42.21%). ADR mainly occurred within 1 day and 1-2 day after medication. Among the reporting staff, 216 cases were reported by pharmacists, 17 cases by physicians and 3 cases by nurses. The most of ADR were improved or recovered after treatment. Conclusion ADR should be considered comprehensively and monitoring should be strengthened to ensure the safety of clinical use of antibiotics in children. |
Key words: Children Antibacterial drug Adverse drug reaction Pareto method |
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