| 引用本文: | 曹雨欣,王喆,赵立,徐磊,尹秀莲,徐为民,王道营,董佳佳,夏秀东.胆红素生理功能及获取途径的研究进展[J].中国现代应用药学,2025,42(9):168-175. |
| Caoyuxin,Wangzhe,Zhaoli,Xulei,Yinxiulian,Xuweimin,Wangdaoying,Dongjiajia,Xiaxiudong.Progress in the Study of Bilirubin Physiological Function and Acquisition Pathway[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(9):168-175. |
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| 胆红素生理功能及获取途径的研究进展 |
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曹雨欣1, 王喆1, 赵立2, 徐磊2, 尹秀莲2, 徐为民1, 王道营1, 董佳佳3, 夏秀东4
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1.江苏省农业科学院;2.淮阴工学院;3.南京中医药大学;4.江苏省农业科学院农产品加工研究所
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| 摘要: |
| 胆红素是人体衰老红细胞的代谢产物，尽管其在较高的浓度下具有一定的毒性，但近年的研究表明胆红素具有潜在的药理作用，包括抗氧化、抗炎及和神经保护等。此外，胆红素也是人工牛黄的主要原料，其含量是评价人工牛黄的重要指标。目前，胆红素的主要来源是从动物胆汁中提取，然而胆红素在胆汁中含量低，且动物胆源资源有限，导致其生产成本高昂。胆红素是一种复杂的分子，同时它在水中的溶解度很低，这些导致其化学合成较为困难且纯度较低。近年来，固定化酶技术和微生物细胞工厂的构建在生物合成胆红素及其前体物质方面取得了显著进展，为胆红素的生产提供了新的途径。本文通过在Web of Science、CNKI和PubMed文献数据库检索近5年的国内外文献，对胆红素的生理功能、获取、合成现状进行了总结归纳，以期为胆红素未来进一步应用提供参考。 |
| 关键词: 胆红素 血红素 生理功能 胆红素合成 |
| DOI： |
| 分类号:R966 |
| 基金项目:肝脏转运体介导的甘草酸体内系统暴露调控和药物相互作用机制研究 |
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| Progress in the Study of Bilirubin Physiological Function and Acquisition Pathway |
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Caoyuxin,Wangzhe,Zhaoli,Xulei,Yinxiulian,Xuweimin,Wangdaoying,Dongjiajia,Xiaxiudong
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1.Jiangsu Academy of Agricultural Sciences;2.Huaiyin Institute of Technology;3.Nanjing University of Chinese Medicine
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| Abstract: |
| Bilirubin is a metabolite of senescent red blood cells in the human body. Although it possesses certain toxicity at higher concentrations, recent studies have shown that bilirubin has potential pharmacological effects, including antioxidant, anti-inflammatory and neuroprotective effects, making it a potential therapeutic agent. In addition, bilirubin is also the main raw material for the artificial cow-bezoar, and its content serves as a crucial criterion for assessing the quality of artificial bezoar. Currently, the main source of bilirubin is extracted from animal bile, however, the low content of bilirubin in bile and the limited resources of animal bile sources lead to its high production cost. Bilirubin is a complex molecule, and its low solubility in water makes its chemical synthesis difficult and its purity low. In recent years, immobilised enzyme technology and the construction of microbial cell factories have made remarkable progress in the biosynthesis of bilirubin and its precursor substances, providing a new pathway for the production of bilirubin and its application as a pharmaceutical preparation. This review summarizes the physiological functions, acquisition, and current synthesis status of bilirubin based on a review of domestic and international literature from the past five years, retrieved from the Web of Science, CNKI, and PubMed databases, with the aim of providing a reference for the further application of bilirubin in the future. |
| Key words: bilirubin heme physiologic function bilirubin production |
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