| 引用本文: | 闫晓萌,冯开元,周瑶,倪铭,周萍.脂肪乳剂在新生儿营养支持中的作用：研究进展与未来方向[J].中国现代应用药学,2025,42(9):160-167. |
| YAN Xiao meng,FENG Kaiyuan,ZHOU Yao,NI Ming,ZHOU Ping.The role of fat emulsions in neonatal nutritional support: research progress and future directions[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(9):160-167. |
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| 摘要: |
| 脂肪乳剂是新生儿肠外营养的重要组成部分,对满足其能量和必需脂肪酸需求至关重要。本文回顾了脂肪乳剂在新生儿肠外营养中的研究进展,重点探讨了其作用、类型、临床应用以及未来研究方向。传统大豆油脂肪乳剂因其局限性逐渐被新型脂肪乳剂所取代,例如中链脂肪乳剂、橄榄油脂肪乳剂、鱼油脂肪乳剂和多种油脂肪乳剂等。这些新型脂肪乳剂在提供更均衡的脂肪酸比例、降低胆汁淤积风险、改善免疫功能等方面展现出优势。然而,其长期安全性、对不同早产儿生长发育的影响以及对新生儿其他并发症的影响仍需进一步研究。本文还讨论了脂肪乳剂的剂量、开始时间、种类选择等临床应用问题,并提出了未来研究方向,以期更好地指导临床实践并改善新生儿肠外营养支持的效果。 |
| 关键词: 脂肪乳剂 新生儿 肠外营养 研究进展 |
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| The role of fat emulsions in neonatal nutritional support: research progress and future directions |
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YAN Xiao meng, FENG Kaiyuan, ZHOU Yao, NI Ming, ZHOU Ping
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Shaoxing Maternity and Child Health Care Hospital
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| Abstract: |
| Fat emulsions are an important component of parenteral nutrition for neonates and are essential for meeting their energy and essential fatty acid requirements. This article reviews the research progress of fat emulsions in neonatal parenteral nutrition, focusing on their role, types, clinical applications, and future research directions. Traditional soybean oil fat emulsions are gradually being replaced by novel fat emulsions due to their limitations, such as medium-chain fat emulsions, olive oil fat emulsions, fish oil fat emulsions, and multi-oil fat emulsions. These newer fat emulsions have shown advantages in providing a more balanced fatty acid ratio, reducing the risk of cholestasis, and improving immune function. However, their long-term safety, effects on the growth and development of different preterm infants, and effects on other neonatal complications still need to be further investigated. This article also discusses the clinical application of fat emulsions, such as dose, start time, and type selection, and proposes future research directions to better guide clinical practice and improve the outcome of parenteral nutritional support in neonates. |
| Key words: lipid emulsion neonate parenteral nutrition research progress |
