| 引用本文: | 迟同霞,甘春雨,丁媛媛,梁国栋,李瑞娟.ROS响应性纳米复合水凝胶递送系统的研究进展[J].中国现代应用药学,2025,42(6):161-168. |
| Chi tongxia,Gan chunyu,Ding yuanyuan,Liang guodong,Li ruijuan.Advances in ROS-responsive Nanocomposite Hydrogel Delivery Systems[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(6):161-168. |
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| 摘要: |
| 水凝胶是一种三维交联聚合物网络，由于其易于控制溶质传递和良好的生物相容性，被广泛应用于药物制剂研究。传统水凝胶力学强度差和药物释放不可控，阻碍其作为纳米药物智能递送材料。研究表明，将纳米颗粒与水凝胶复合可以提升水凝胶机械性能，改善其力学性能，在递送系统中引入响应基团可实现按需释放药物，且保护药物结构完整性。活性氧（Reactive oxygen species，ROS）响应性纳米复合水凝胶递送系统是将功能性的响应材料应用到新型递送系统中，这不仅对ROS过表达的疾病部位具有一定靶向和促药物释放作用，而且结合了纳米粒和水凝胶两种药物载体优势，弥补了单一载体的缺陷，使其具有更强的化学、物理或生物学特性，具有良好的发展前景。本文综述了基于不同ROS响应的化学键或基团在纳米复合水凝胶递送系统中的应用，以期为开发更多功能性响应材料在药物递送系统中应用提供思路。 |
| 关键词: ROS响应 纳米粒 水凝胶 纳米递送系统 |
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| 基金项目:内蒙古医科大学校级面上项目（YKD2023MS074）；内蒙古自治区高等学校“青年科技英才支持计划”（NJYT-20-B26）；内蒙古自治区高校科研项目（NJZZ23002）；内蒙古自治区自然科学基金联合基金项目（2023LHMS08011）；内蒙古医科大学学科项目创新药物制剂的研究（YKD2023XK017）。 |
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| Advances in ROS-responsive Nanocomposite Hydrogel Delivery Systems |
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Chi tongxia, Gan chunyu, Ding yuanyuan, Liang guodong, Li ruijuan
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College of Pharmacy, Inner Mongolia Medical University,
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| Abstract: |
| Hydrogel, a three-dimensional cross-linked polymer network, is a widely utilised component of pharmaceutical development, due to its easily controllable solute transfer properties and favourable biocompatibility. Poor mechanical strength and uncontrolled drug release of conventional hydrogels represent significant obstacles to their utilisation as medical materials. It has been demonstrated that the incorporation of nanoparticles into hydrogels can result in enhanced mechanical properties. Furthermore, the incorporation of responsive groups into drug delivery systems can facilitate the controlled release of drugs while maintaining the structural integrity of the system. A reactive oxygen species (ROS)-responsive nanocomposite hydrogel delivery system represents the application of functional responsive materials to a novel delivery system. This system has the potential to achieve a targeted and controlled release of pro-drugs at disease sites exhibiting ROS overexpression. Furthermore, it combines the advantages of both nanoparticles and hydrogels as drug carriers, thereby addressing the limitations of a single carrier. This approach could result in the development of more robust chemical, physical, or biological properties. This paper reviews the application of different ROS-responsive chemical bonds or groups in nanocomposite hydrogel delivery systems, with a view to providing ideas for the development of more multifunctional responsive materials for application in drug delivery systems. |
| Key words: ROS response nanoparticle hydrogel nanodelivery system |
