| 引用本文: | 袁楚,刘想,高如汐,王凡一,张可,吴昊,刘思奇,赵启苗,单国顺.基于多指标-响应面法优选土炒白术的炮制工艺[1][J].中国现代应用药学,2024,41(14):88-97. |
| YUAN Chu,LIU Xiang,GAO Ru-xi,WANG Fan-yi,ZHANG Ke,WU Hao,LIU Si-qi,ZHAO Qi-miao,SHAN Guo-shun.Based on the method of multi-index-response surface? method to optimize the processing of soil-fried Atractylodis Macrocephalae Rhizoma(AMR)[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(14):88-97. |
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| 基于多指标-响应面法优选土炒白术的炮制工艺[1] |
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袁楚1, 刘想1, 高如汐1, 王凡一1, 张可1, 吴昊1, 刘思奇1, 赵启苗2, 单国顺1
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1.辽宁中医药大学;2.辽宁医药职业学院
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| 摘要: |
| 目的 对土炒白术的炮制工艺进行优化。方法 采用紫外可见分光光度法和超高效液相色谱-三重四极杆串联质谱（UPLC-QqQ-MS/MS）技术对土炒白术中多糖含量以及白术内酯Ⅰ、白术内酯Ⅱ、白术内酯Ⅲ等活性成分的含量进行测定，采用色差仪对土炒白术粉末色度值进行分析；将上述化学成分的含量以及饮片的色度作为评价指标，采用单因素试验法对土炒白术过程中的辅料用量、炒制温度、炒制时间进行考察；通过层次分析-赋值（analytic hierarchy process and criteria importance through inter criteria correlation，AHP-CRITIC）混合加权法结合Box-Behnken响应面法进行土炒白术炮制工艺的优化研究。结果 优化土炒白术的最佳炮制工艺为每50 g药材用灶心土28.4 g，在204 ℃下炒制5.30 min。结论 本实验确定的土炒白术工艺切实可行，可为该炮制品的工业化生产中提供一定的指导意义。 |
| 关键词: 白术 土炒 混合加权法 响应面法 工艺优化 |
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| Based on the method of multi-index-response surface? method to optimize the processing of soil-fried Atractylodis Macrocephalae Rhizoma(AMR) |
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YUAN Chu1, LIU Xiang1, GAO Ru-xi1, WANG Fan-yi1,1, ZHANG Ke1, WU Hao1, LIU Si-qi1, ZHAO Qi-miao2, SHAN Guo-shun1
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1.Liaoning University of Traditional Chinese Medicine;2.Liaoning Vocational College of Medicine
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| Abstract: |
| Objective Optimize the processing technology of soil stir-fried AMR. Methods By using Uv-Visible Spectrophotometry and Ultra-Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry (UPLC-QqQ-MS/MS) to determine the content of polysaccharides and active ingredients such as atractylenolideⅠ, atractylenolideⅡ, atractylenolide Ⅲ etc. The colorimeter was used to determine the color value of soil-fried AMR powder. The contents of the above chemical components and the color value of soil-fried AMR pieces were used as evaluation indexes. The single factor trial method was adopted to investigate the amount of excipients,,stir-frying temperature and time of AMR. The analytic hierarchy process and criteria importance through inter criteria correlation (AHP-CRITIC) combined with the method of Box-Behnken response surface to design and optimize the processing technology of soil stir-fried AMR. Results The best processing technology of soil fried AMR were optimized to 28.4 g of soil added to 50 g of medicinal materials which was fried 5.30 min in 204℃. Conclusion The process of soil stir-fried AMR determined in this experiment is feasible which can provide certain guiding significance for the industrial production of the processed products. |
| Key words: Atractylodis Macrocephalae Rhizoma Soil-fried Analytic hierarchy process and criteria importance through inter criteria correlation Box-Behnken response surface method Process optimization |
