基于响应面法结合熵权法优选浙贝母（灰贝）加工工艺的研究

李莉; 杨先启; 陈军; 张叶峰; 邵将炜

引用本文:	李莉,杨先启,陈军,张叶峰,邵将炜.基于响应面法结合熵权法优选浙贝母（灰贝）加工工艺的研究[J].中国现代应用药学,2024,41(14):70-77.
	LiLi,Yang Xianqi,Chen Jun,Zhang Yefeng,Shao Jiangwei.Study on optimization of Fritillaria thunbergii（huibei）processing technology based on response surface method combined with entropy weight method[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(14):70-77.

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基于响应面法结合熵权法优选浙贝母（灰贝）加工工艺的研究
李莉¹, 杨先启¹, 陈军¹, 张叶峰², 邵将炜³
1.宁波市药品检验所;2..宁波市中药饮片有限公司;3.宁波小贝农农业科技有限公司

摘要:

目的：应用响应面法结合熵权法优化浙贝母(灰贝)的加工工艺。方法：以伊贝辛、贝母辛、贝母素甲、贝母素乙、异贝母甲素为考察指标,熵权法确定各指标成分权重,在单因素实验的基础上,采用Box-Behnken响应面法设计优化浙贝母(灰贝)的加工工艺。结果：得到最优提取工艺为撞皮时间95 s、料灰比0.9%、发汗时间5 h、干燥温度45 ℃,验证结果与预测值偏差为0.5%。结论：响应面法优选的加工工艺稳定性好,可操作性强,可为灰贝产地加工炮制一体化的质量控制提供科学依据。

关键词: 浙贝母(灰贝) 响应面法加工工艺生物碱熵权法

DOI：

分类号:

基金项目:浙贝母传统工艺灰贝的研究

Study on optimization of Fritillaria thunbergii（huibei）processing technology based on response surface method combined with entropy weight method

LiLi¹, Yang Xianqi¹, Chen Jun¹, Zhang Yefeng², Shao Jiangwei³

1.Zhejiang Ningbo Institute for Drug Control;2.Ningbo Chinese Medicine Yiinpian Co.，Ltd.;3.Ningbo Xiao be nong Agricultural Technology Co.， Ltd.

Abstract:

ABSTRACT: OBJECTIVE To optimize the processing technology of Fritillaria thunbergii（huibei）by response surface methodology combined with entropy weight method. METHODS The single factor experiment combined with Box-Behnken design was used to optimize the the processing technology, with five kinds of alkaloid (yibeissine, peimisine, peimine, peiminine, isobeta metrin ) as the inspection indicators, combined with the weight coefficients were calculated by entropy weight method. RESULTS The optimum extraction process was determined as following: crashing time for 95 seconds, material-to-ash ratio for 0.9%, sweating time for 5 hours, and drying temperature for 45℃. The RSD between the validation results and the predicted values is 0.5%.CONCLUSION This optimized processing technology is stable amd feasible, which can provide the scientific basis for quality control of huibei processing technology.

Key words: Fritillaria thunbergii(huibei) response surface method processing technology alkaloids entropy weight method