| 引用本文: | 熊慧利,李凤凤,蒋盼云,李荣东.增殖细胞核抗原(PCNA)抑制剂的研究进展[J].中国现代应用药学,2025,42(8):176-185. |
| XiongHuili,Li Fengfeng,Jiang Panyun,Li Rongdong.Research progress of proliferating cell nuclear antigen (PCNA) inhibitors[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(8):176-185. |
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| 摘要: |
| 摘要：恶性肿瘤危害着许多人的生命,增殖细胞核抗原（proliferating cell nuclear antigen, PCNA）在不同恶性肿瘤组织中的异常表达与肿瘤细胞的增殖、预后以及检测都有一定关系。PCNA可以作为恶性肿瘤治疗的理想靶点，通过PCNA的抑制研究可以发现一条新的抗癌途径，对于多种恶性肿瘤的治疗起着举足轻重的作用。“抗癌神药”AOH1996的发现标志着特异性靶向PCNA的重大进展，探索高效安全的PCNA抑制剂受到越来越多的关注，本文以PCNA与肿瘤的关系为基础，对PCNA抑制剂的结构特点、作用机制、抗癌活性等方面的研究进行总结概括。 |
| 关键词: 恶性肿瘤 PCNA PCNA抑制剂 |
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| 基金项目:湖南中医药大学药学一流学科开放基金重点资助项目（2021YX01） |
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| Research progress of proliferating cell nuclear antigen (PCNA) inhibitors |
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XiongHuili, Li Fengfeng, Jiang Panyun, Li Rongdong
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School of Pharmacy, Hunan University of Traditional Chinese Medicine
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| Abstract: |
| Malignant tumors endanger the lives of many people. The abnormal expression of proliferating cell nuclear antigen (proliferatingcellnuclearantigen,PCNA) in different malignant tumors is related to the proliferation, prognosis and detection of tumor cells. PCNA can be used as an ideal target for the treatment of malignant tumors. A new anticancer pathway can be found through the inhibition of PCNA, which plays an important role in the treatment of many kinds of malignant tumors. The discovery of "anticancer drug" AOH1996 marks a great progress in specifically targeting PCNA. The exploration of efficient and safe PCNA inhibitors has attracted more and more attention. Based on the relationship between PCNA and tumor, this paper summarizes the structural characteristics, mechanism of action and anticancer activity of PCNA inhibitors. |
| Key words: Malignant tumor PCNA PCNA inhibitor. |
