| 引用本文: | 刘帅,荣晓辉,张书锋,屈磊,刘芳,井娟*.纳豆激酶递送系统研究进展[J].中国现代应用药学,2024,41(9):1295-1302. |
| LIU Shuai,RONG Xiaohui,ZHANG Shufeng,QU Lei,LIU Fang,JING Juan*.Research Progress of Nattokinase Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(9):1295-1302. |
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| 摘要: |
| 血栓栓塞性疾病严重影响着人们的身心健康，甚至危害生命。纳豆激酶(nattokinase，NK)是一种碱性丝氨酸蛋白酶，具有溶栓活性强、不良反应小等优点。但NK经口服给药，会被胃酸和胃蛋白酶降解，失去溶栓活性。采用制剂技术可以形成保护层，提高NK的生物利用度。本文简要介绍了NK的药理性质，讨论了NK不同剂型的特性，对NK制剂的发展进行了展望，以期促进其研究和应用。 |
| 关键词: 蛋白酶 纳豆激酶 溶栓 剂型 |
| DOI：10.13748/j.cnki.issn1007-7693.20230014 |
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| Research Progress of Nattokinase Delivery System |
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LIU Shuai1, RONG Xiaohui1, ZHANG Shufeng1, QU Lei1, LIU Fang2, JING Juan*1
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1.Department of Medical Technology Support, NCOs Academy of Army Medical University, Shijiazhuang 050081, China;2.Jingnan Medical District of PLA General Hospital, Beijing 100036, China
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| Abstract: |
| Thromboembolic disease seriously affects people's health, and even endangers life. Nattokinase(NK) is an alkaline serine protease with strong thrombolytic activity and low toxicity. However, when NK passes through the stomach, it is degraded by gastric acid and pepsin, and subsequently loses its thrombolytic activity. The application of preparation technology can form a protective layer and improve the high bioavailability of NK. This article briefly introduced the pharmacological properties of NK, and discussed the characteristic of different dosage forms. The development of NK preparation was prospected in order to promote its research and application. |
| Key words: protease nattokinase thrombolysis dosage form |
