| 引用本文: | 姚梦圆,赵丽蓉,黎晨,张珂璇,周本宏.化疗相关认知障碍的研究现状与进展[J].中国现代应用药学,2025,42(7):189-195. |
| yaomengyuan,zhaolirong,lichen,zhangkexuan,zhoubenhong.Research status and progress of chemotherapy-related cognitive impairment[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(7):189-195. |
|
| 摘要: |
| 目前，临床上手术前后治疗癌症的药物多为化疗药物。虽然化疗药物的使用提高了癌症患者的生存率，但这些药物可能会带来严重的副作用，这些副作用显著降低了化疗药物的疗效和癌症患者的生活质量。化疗相关认知障碍（chemotherapy-related cognitive impairment，CRCI）是接受化疗的患者面临的一个重大问题，在缺乏标准治疗的情况下，CRCI的发病率正在逐年增加，其严重降低了患者的生活质量。尽管临床上已经足够重视CRCI，但其发病机制尚未完全明确，仅能予以抗抑郁药、抗痴呆药、抗氧化剂等药物对症处理，然而这些药物作用局限、单一，故而积极探索安全且有效的药物干预方法成为当前研究的方向。本综述总结了既往研究CRCI的相关文献，重点介绍了动物和临床研究中CRCI可能的潜在发病机制，并强调了几种可能有助于治疗CRCI的药物，期待研究人员找到有效的药物治疗手段。 |
| 关键词: 化疗相关认知障碍 炎症 血脑屏障 氧化应激 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Research status and progress of chemotherapy-related cognitive impairment |
|
yaomengyuan, zhaolirong, lichen, zhangkexuan, zhoubenhong
|
|
Department of Pharmacy, Renmin Hospital of Wuhan University
|
| Abstract: |
| At present, most of the drugs used to treat cancer before and after surgery are chemotherapy drugs. While the use of chemotherapy drugs improves the survival rate of cancer patients, these drugs can come with serious side effects that significantly reduce the efficacy of chemotherapy drugs and the quality of life of cancer patients. Chemotherapy-related cognitive impairment (CRCI) is a major problem for patients receiving chemotherapy, and the incidence of CRCI is increasing year by year in the absence of standard treatment, which seriously reduces the quality of life of patients. Although CRCI has attracted enough attention in clinical practice, its mechanism has not yet been fully understood, and it can only be treated symptomatically with antidepressants, antidementia, antioxidants and other drugs, and the effect is limited and single, so actively exploring safe and effective drug intervention methods has become the direction of current research. This review summarizes the relevant literature on previous studies of CRCI, highlights the possible potential pathogenesis of CRCI in animal and clinical studies, and highlights several drugs that may help in the treatment of CRCI, in anticipation of the investigators' finding effective drug treatments. |
| Key words: Chemotherapy-related cognitive impairment Inflammation BBB Oxidative stress |
