| 引用本文: | 赵悦名,于桐,李文婧,王佳雯*.外泌体介导的细胞间通讯在炎症性肠病中作用的研究进展[J].中国现代应用药学,2024,41(5):709-715. |
| ZHAO Yueming,YU Tong,LI Wenjing,WANG Jiawen*.Research Progress in the Role of Exosome-mediated Intercellular Communication in Inflammatory Bowel Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(5):709-715. |
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| 摘要: |
| 外泌体是细胞分泌/衍生的囊泡状纳米颗粒，其介导了一种新型的细胞间通讯方式。细胞分泌型mRNA和microRNAs(miRNAs)可随着外泌体在细胞间进行功能转移，并被送入受体细胞作为内源性miRNAs发挥作用，同时调节多个目标基因或信号。外泌体等外囊泡介导的细胞间通讯以及肠道微生物群-宿主细胞通讯参与了炎症性肠病发生、发展相关的状况。本文回顾外泌体在细胞间通讯的方式作用，从细胞间通讯的角度讨论外泌体在炎症性肠病的发病机制、病情进展、治疗诊断中的作用及其临床应用前景。 |
| 关键词: 外泌体 炎症性肠病 细胞间通讯 miRNAs |
| DOI：10.13748/j.cnki.issn1007-7693.20230349 |
| 分类号:R966 |
| 基金项目:吉林省教育厅科学技术研究项目(JJKH20220875KJ)；吉林省大学生创新创业训练项目(S202110199129X) |
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| Research Progress in the Role of Exosome-mediated Intercellular Communication in Inflammatory Bowel Disease |
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ZHAO Yueming, YU Tong, LI Wenjing, WANG Jiawen*
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Chinese Medicine Health Innovation Center, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China
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| Abstract: |
| Exosomes are cell-secreted/derived vesicular nanoparticles that mediate a novel form of intercellular communication. Cell secreted mRNA and microRNAs(miRNAs) can undergo functional transfer between cells with exosomes and be delivered to recipient cells as endogenous miRNAs, while regulating multiple target genes or signals. The intercellular communication mediated by exosomes and intestinal microbiome-host cell communication are involved in the pathogenesis and development of inflammatory bowel disease(IBD). This paper review the role of exosomes in the mode of cell communication, and discuss the pathogenesis, progression, therapeutic and diagnostic role of exosomes in IBD, as well as its clinical application prospects, in perspective of intercellular communication. |
| Key words: exosome inflammatory bowel disease intercellular communication miRNAs |
