| 引用本文: | 杨春红,李姝,赵琪,石倩,甘彦雄,赖先荣*,李睿*.基于AHP-CRITIC赋权法优化明目益睛丸成型工艺[J].中国现代应用药学,2024,41(5):672-677. |
| YANG Chunhong,LI Shu,ZHAO Qi,SHI Qian,GAN Yanxiong,LAI Xianrong*,LI Rui*.Optimization of the Forming Process of Mingmu Yijing Pills Based on AHP-CRITIC Mixed Weighting Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(5):672-677. |
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| 摘要: |
| 目的 明确权重指标，优选复方明目益睛成丸工艺。方法 以水分、溶散时限、成丸合格率为评价指标，采用层次分析法(analytic hierarchy process，AHP)、基于指标客观性的权重赋权法(criteria importance through inter-criteria correlation，CRITIC)、AHP-CRITIC混合加权法，计算各指标的相对系数进行权重分配并综合评分，结合Box-Behnken响应面试验优化成型工艺，并加以验证。结果 AHP-CRITIC混合加权法的合理及稳定性优于单一赋权法，该方法最终优选出明目益睛丸的成型工艺条件：加水量为0.8倍量，软材浸润0.5 h，干燥温度60 ℃，干燥时间8 h。重复验证实验综合评分均值88.21，RSD为0.29%。结论 AHP-CRITIC法科学确定多指标权重，经验证试验证实了优选出的成型工艺稳定可行，可用于实际规模化生产。 |
| 关键词: 明目益睛丸 成型工艺 AHP法 CRITIC法 AHP-CRITIC混合加权法 Box-Behnken响应面 |
| DOI：10.13748/j.cnki.issn1007-7693.20224045 |
| 分类号:R285.5 |
| 基金项目: |
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| Optimization of the Forming Process of Mingmu Yijing Pills Based on AHP-CRITIC Mixed Weighting Method |
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YANG Chunhong1, LI Shu2, ZHAO Qi1, SHI Qian1, GAN Yanxiong1, LAI Xianrong*1, LI Rui*2
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1.Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;2.Meishan Hospital of Traditional Chinese Medicine, Meishan 620000, China
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| Abstract: |
| OBJECTIVE To clarify the weight index and optimize the technology of compound Mingmu Yijing pills. METHODS Water content, dissolution time limit and bolus-forming pass rate were included as evaluation indexes. The analytic hierarchy process(AHP) and the criterion importance through inter-criteria correlation(CRITIC) method based on the objectivity of indicators were adopted, AHP-CRITIC mixed weighting method. In this way, the relative coefficients of each index were calculated for weight distribution and comprehensive score, and the molding process was optimized and verified by Box-Behnken response surface test. RESULTS Compared with the single weighting method, the AHP-CRITIC mixed weighting method was more reasonable and stable. This method finally optimized the forming process conditions of Mingmu Yijing pills as follows: adding water amount of 0.8 times, the damp mass infiltration for 0.5 h, drying temperature of 60 ℃, drying time of 8 h. The mean comprehensive score of validation experiment was 88.21, RSD was 0.29%. CONCLUSION AHP-CRITIC method scientifically determines the weight of multiple indicators, and the verification test confirms that the optimized molding process is stable and feasible, which can be used in practical large-scale production. |
| Key words: Mingmu Yijing pills forming process AHP CRITIC AHP-CRITIC mixed weighting method Box-Behnken response surface method |
