| 引用本文: | 王熙媛,季世春,程建明,何倩灵,赵楚文,向柳.运用层次分析法对三七药材灭菌方式的探讨[J].中国现代应用药学,2025,42(8):47-55. |
| wangxiyuan,季世春,程建明,何倩灵,赵楚文,向柳.Discussion on the sterilization method of Radix Notoginseng with analytic hierarchy process[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(8):47-55. |
|
| 摘要: |
| 目的：确定三七药材最佳灭菌方式。方法：以微生物限度、性状、指纹图谱相似度、浸出物与含量差值百分比及灭菌操作难易程度为指标,建立其“微生物-理化”多维度质量评价体系,对比湿热灭菌、乙醇灭菌、高温瞬时灭菌、电子束辐照灭菌四种方式的灭菌效果,采用AHP层次分析法确定权重系数。结果：四种灭菌方式均满足三七药材的微生物限度要求,但乙醇灭菌和湿热灭菌不同程度地改变了其外观颜色、浸出物含量、人参皂苷Rg1、人参皂苷Rb1和三七皂苷R1含量总量,且指纹图谱相似度较低；高温瞬时灭菌和电子束辐照灭菌前后三七理化指标无显著变化,指纹图谱相似度均在0.997以上,但高温瞬时灭菌操作降低企业生产效率。结论：选择电子束辐照灭菌作为三七药材的灭菌方式,暂定辐照剂量为9.0 kGy。本研究为三七打粉入药前采用电子束辐照灭菌在中药前处理中的应用提供了实践基础。 |
| 关键词: 三七 前处理 灭菌方式 层次分析法 质量评价 |
| DOI：10.13748/j.cnki.issn1007-7693.20233423 |
| 分类号: |
| 基金项目: |
|
| Discussion on the sterilization method of Radix Notoginseng with analytic hierarchy process |
|
wangxiyuan, 季世春, 程建明, 何倩灵, 赵楚文, 向柳
|
|
Nanjing University of Traditional Chinese Medicine
|
| Abstract: |
| Objective: To determine the best sterilization method of Panax notoginseng medicinal materials. Methods: A multi-dimensional quality evaluation system of "microorganism-physicochemical" was established based on microbial limits, traits, fingerprint similarity, percentage difference between extract and content and difficulty of sterilization operation, and the weight coefficient was determined by AHP analytic hierarchy method by comparing the sterilization effects of humid heat sterilization, ethanol sterilization, high temperature instantaneous sterilization and electron beam irradiation sterilization. Results: The four sterilization methods all met the microbial limit requirements of Panax notoginseng medicinal materials, but ethanol sterilization and moist heat sterilization changed the total content of ginsenoside Rg1, ginsenoside Rb1 and Panax notoginseng saponin R1 to varying degrees, and the fingerprint similarity was low. There was no significant change in the physical and chemical indexes of Panax notoginseng before and after high-temperature instantaneous sterilization and electron beam irradiation sterilization, and the similarity of fingerprints was above 0.997, but the high-temperature instantaneous sterilization operation reduced the production efficiency of enterprises. Conclusion: Electron beam irradiation sterilization was selected as the sterilization method for Panax notoginseng medicinal materials, and the tentative irradiation dose was 9.0 kGy. This study provides a practical basis for the application of electron beam irradiation sterilization in the pretreatment of traditional Chinese medicine before the use of Panax notoginseng powder before entering the drug. |
| Key words: Sanchi pre-treatment Sterilization method analytic hierarchy Quality evaluation |
