| 引用本文: | 汪春梅,安方玉,颜春鲁,柳颖,王霞霞,孙柏,张捷,肖志攀,王玉洁,常伟荣,宋佳眙.从线粒体角度探讨PARK家族在慢性骨病中的研究进展[J].中国现代应用药学,2025,42(7):178-188. |
| wang chun mei,an fang yu,yan chun lu,liu ying,wang xia xia,sun bai,zhang jie,xiao zhi pan,wang yu jie,chang wei rong,song jia yi.Research progress on the PARK family in chronic bone disease based on the perspective of mitochondria[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(7):178-188. |
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| 从线粒体角度探讨PARK家族在慢性骨病中的研究进展 |
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汪春梅, 安方玉, 颜春鲁, 柳颖, 王霞霞, 孙柏, 张捷, 肖志攀, 王玉洁, 常伟荣, 宋佳眙
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甘肃中医药大学
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| 摘要: |
| 线粒体与决定细胞命运的多种生物过程密切相关,能够参与真核生物的氧化代谢,三羧酸循坏,能量转化,氧化磷酸化等,其结构及功能的异常是慢性骨病发病的核心环节。研究发现,PARK家族成员能够通过介导线粒体自噬等参与慢性骨病的发生发展过程,但具体分子机制未明。基于此,本文主要总结近年来PARK1、PARK2、PARK5、PARK6和PARK7等PARK家族成员介导的线粒体自噬、氧化应激、能量代谢在慢性骨病发生发展过程中的分子调控机制,以期为慢性骨病的临床诊治及靶向治疗提供依据。 |
| 关键词: PARK基因家族 慢性骨病 线粒体自噬 线粒体氧化应激 线粒体能量代谢 |
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| Research progress on the PARK family in chronic bone disease based on the perspective of mitochondria |
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wang chun mei, an fang yu, yan chun lu, liu ying, wang xia xia, sun bai, zhang jie, xiao zhi pan, wang yu jie, chang wei rong, song jia yi
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Gansu University of Traditional Chinese Medicine
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| Abstract: |
| ABSTRACT: Mitochondria play a significant role in numerous biological processes that govern cellular destiny, encompassing eukaryotic oxidative metabolism, tricarboxylic acid cycling, energy conversion, and oxidative phosphorylation. Perturbations in their structure and function serve as pivotal factors in chronic bone diseases. Research has indicated that the involvement of PARK family members in mitochondrial autophagy may contribute to the initiation and progression of chronic bone diseases; however, the precise molecular mechanism underlying this association remains elusive.Hence, this review primarily presents a comprehensive overview of the molecular regulatory pathways involving mitochondrial autophagy, oxidative stress, and energy metabolism, which are mediated by PARK family members including PARK1, PARK2, PARK5, PARK6, and PARK7, in the pathogenesis and progression of chronic bone disorders in recent times. In order to furnish substantiated evidence for the clinical diagnosis, treatment, and targeted therapeutic interventions for chronic bone diseases. |
| Key words: PARK gene family chronic bone disease mitochondrial autophagy mitochondrial oxidative stress mitochondrial energy metabolism |
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