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引用本文:葛燕,沈咏梅,刘姝,曾陈娟,耿福能.“促修复为主”治疗消化性溃疡的探讨[J].中国现代应用药学,2025,42(8):170-175.
Ge yan,Shen yongmei,Liu shu,Zeng chenjuan,Geng funeng.Treating peptic ulcer focusing mainly on repair[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(8):170-175.
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“促修复为主”治疗消化性溃疡的探讨
葛燕, 沈咏梅, 刘姝, 曾陈娟, 耿福能
药用美洲大蠊四川省重点实验室
摘要:
长久以来对消化性溃疡动辄抑酸的治疗习惯导致抑酸剂不合理用药增多,不良反应报道日益增多,溃疡复发率居高不下。实际上胃酸是一种正常的生理性存在,并不是消化性溃疡发生的原罪。消化道黏膜屏障的损伤才是溃疡发生的根本原因,促进溃疡愈合的关键在于尽快修复受损的黏膜屏障。文中提出消化性溃疡的治疗应该以“促进修复为主,抑制胃酸为辅”,并从抑酸剂存在的问题、消化性溃疡的发病机制、修复类药物的疗效和存在问题等几个方面详细论述了这一主张的合理性和科学性。
关键词:  消化性溃疡  胃酸  黏膜  修复
DOI:
分类号:R
基金项目:基于网络药理学与肠道微生态的康复新液治疗肠易激综合征的机制研究
Treating peptic ulcer focusing mainly on repair
Ge yan, Shen yongmei, Liu shu, Zeng chenjuan, Geng funeng
Medicinal Periplaneta Americana Key Laboratory of Sichuan Province
Abstract:
The long-standing habit in treating peptic ulcers with acid suppressants had contributed to their abused using, and led to increasing adverse reactions and recurrence rate. In fact, acid suppression was only a way to weaken damage factors. Improving the repair ability of the tissue should be the key for ulcer healing. Therefore, it was proposed that "repairing the injury mainly and inhibiting acid secretion accessorily" should be the basic principle for peptic ulcer. This article discussed the rationality and scientificity of this advocation in detail in terms of the problems with acid suppressants, the pathogenesis of peptic ulcer, the curative effects and problems of repairing drugs.
Key words:  peptic ulcer  gastric acid  mucous membrane  repair
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