| 引用本文: | 梁慧慧,谭亲友.雷公藤萜类化合物的抗肿瘤作用机制及联合治疗研究进展[J].中国现代应用药学,2025,42(6):122-129. |
| Liang Hui-hui,TAN Qin-you.Research Progress on Anti-tumor Mechanism and Combined therapy of terpenoids from Tripterygium wilfordii[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(6):122-129. |
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| 摘要: |
| 恶性肿瘤是严重威胁人类健康的重大慢性病，成为各国卫生组织需要解决的难题。手术切除并联合药物辅助治疗是抗肿瘤治疗的主要手段，但如今的抗肿瘤药物多存在耐药性和毒副作用。随着近年来肿瘤发病率的不断增加，用安全有效的中医药治疗肿瘤成为热点。雷公藤是我国的一种天然化合物，已被证实对多种恶性肿瘤均具有显著治疗效果，有效成分中萜类化合物雷公藤甲素和雷公藤红素被认为是传统中医药治疗肿瘤的代表药物。本文全面阐述了雷公藤萜类化合物发挥抗肿瘤的作用机制，并对其联合治疗进行分析和拓展，以期为雷公藤萜类化合物的深入研究和临床应用提供理论依据和研究思路。 |
| 关键词: 雷公藤 雷公藤萜类化合物 抗肿瘤 作用机制 联合治疗 |
| DOI： |
| 分类号:R285?????? |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）;广西自然科学基金面上基金项目;广西博士研究生创新项目 |
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| Research Progress on Anti-tumor Mechanism and Combined therapy of terpenoids from Tripterygium wilfordii |
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Liang Hui-hui, TAN Qin-you
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Guilin Medical University
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| Abstract: |
| Malignant tumors are a major chronic disease that poses a serious threat to human health, and have become a challenge that health organizations in various countries need to address. Surgical resection combined with drug assisted therapy is the main method of anti-tumor treatment, but nowadays, many anti-tumor drugs have drug resistance and toxic side effects. With the increasing incidence rate of tumors in recent years, the treatment of tumors with safe and effective traditional Chinese medicine has become a hot spot. Tripterygium wilfordii is a natural compound in China, which has been proven to have significant therapeutic effects on various malignant tumors. Among the active ingredients, the terpenoid compounds Tripterygium wilfordii A and Tripterygium wilfordii red are considered representative drugs for traditional Chinese medicine in treating tumors. This article comprehensively elaborates on the anti-tumor mechanism of terpenoids from Tripterygium wilfordii, and analyzes and expands their combined therapy, in order to provide theoretical basis and research ideas for the in-depth research and clinical application of terpenoids from Tripterygium wilfordii. |
| Key words: Tripterygium wilfordii Tripterpenoids Antitumor Mechanism of action Combination therapy |
