| 引用本文: | 王丽桂,吕佳杰,范君婷,都述虎,马坤芳,鞠建明.基于UPLC-ESI-Q-TOF-MS分析中药鸡冠花子的化学成分[J].中国现代应用药学,2024,41(17):34-33. |
| WangLigui,Lvjiajie,FanJunting,Dushuhu,Makunfang,JuJianming.Analysis on Chemical Constituents from the Seeds of Celosia Cristata L. by UPLC-ESI-Q-TOF-MS[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(17):34-33. |
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| 摘要: |
| 目的：应用UPLC-ESI-Q-TOF-MS技术对中药鸡冠花子中化学成分进行定性分析。方法：采用UPLC-ESI-Q-TOF-MS技术采集数据,通过高分辨质谱提供的精确分子量和碎片离子信息,结合SciFinder数据库、青葙属相关文献、对照品信息、裂解规律进行数据分析。结果：从鸡冠花子中共鉴定出76个化学成分,包含13个环肽,18个三萜,16个黄酮,11个酚,6个苯丙素,4个甾体和8个其他类化合物,其中27个化学成分为该种首次发现。并首次归纳荨麻科类型环肽和茄科类型环肽的质谱裂解特点。结论：建立的UPLC-Q-TOF-MS法对鸡冠花子中化学成分进行快速、准确、全面分析,为其质量控制和药效物质基础阐明提供科学依据。 |
| 关键词: 鸡冠花子 UPLC-ESI-Q-TOF-MS 化学成分 环肽 三萜 |
| DOI：10.13748/j.cnki.issn1007-7693.20231078 |
| 分类号: |
| 基金项目:南京中医药大学自然科学基金(XZR2020021) |
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| Analysis on Chemical Constituents from the Seeds of Celosia Cristata L. by UPLC-ESI-Q-TOF-MS |
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WangLigui1, Lvjiajie1, FanJunting2, Dushuhu2, Makunfang2, JuJianming3
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1.Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine;2.Nanjing Medical University;3.Jiangsu Province Academy of Traditional Chinese Medicine
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| Abstract: |
| ABSTRACT: OBJECTIVE Qualitative analysis of the chemical constituents from the seeds of Celosia cristata L. based on UPLC-ESI-Q-TOF-MS. METHODS The data were collected by UPLC-Q-TOF-MS. The constituents were identified the precise molecular weight, fragment ions information, the database of SciFinder, relevant literatures of Celosia, standards and mass fragmentation pattern. RESULTS A total of 76 compounds were identified from the seeds of C. cristata, including 13 cyclopeptides, 18 triterpenoids, 16 flavonoids, 11 phenols, 6 phenylpropanoids, 4 steroids, and 8 other compounds. Among them, 27 compounds were reported for the first time from this species. And this study explores the mass fragmentation pattern of Urticaceae-type cyclopeptides and Solanaceae-type cyclopeptides for the first time. CONCLUSION The study provides a quick, accurate, comprehensive analysis of chemical constituents in the seeds of C. cristata, and so as to provide a scientific basis for the clarification of quality control and pharmacodynamical material basis with the seeds of C. cristata. |
| Key words: the seeds of Celosia cristata L. UPLC-ESI-Q-TOF-MS chemical constituents cyclopeptides triterpenoids |
