杜钩平肝颗粒的制剂及药效学研究

任桂林; 蒲清荣; 杜仕静; 谭正怀; 赵剑; 黄锐; 罗群; 谢春光; 杨思进

引用本文:	任桂林,蒲清荣,杜仕静,谭正怀,赵剑,黄锐,罗群,谢春光,杨思进.杜钩平肝颗粒的制剂及药效学研究[J].中国现代应用药学,2024,41(16):1-0.
	Ren gui lin,Pu Qingrong,Du Shijing,Tan Zhenghuai,Zhao Jian,Huang Rui,Luo Qun,Xie Chunguang,Yang Sijin.Study on Preparation and Pharmacodynamics of Duguopingan Granules[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(16):1-0.

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杜钩平肝颗粒的制剂及药效学研究
任桂林¹, 蒲清荣¹, 杜仕静², 谭正怀², 赵剑¹, 黄锐¹, 罗群¹, 谢春光³, 杨思进¹
1.西南医科大学附属中医医院;2.四川省中医药科学院;3.成都中医药大学附属医院

摘要:

目的：研究杜钩平肝颗粒处方的制备工艺、质量标准及初步药效学,为研制成颗粒剂提供基础。方法：采用正交实验法进行水提工艺研究,以出膏率及葛根素的含量为指标,优选出最佳的水提工艺。采用薄层鉴别及高效液相色谱法对杜钩平肝颗粒进行质量标准研究。研究杜钩平肝颗粒对L-NAME诱导高血压大鼠模型的预防作用。结果：杜钩平肝颗粒处方最佳的提取工艺为：10倍量的水,浸泡1h,煎煮1.5h,煎煮3次。质量标准为：以葛根素作为含量测定指标,以盐酸小檗碱、川牛膝、盐酸水苏碱作为鉴别指标。药效学试验结果表明,杜钩平肝颗粒低剂量组能降低大鼠收缩压和平均动脉压,杜钩平肝颗粒高剂量组能降低大鼠收缩压。结论：杜钩平肝颗粒制备工艺稳定可行,且具有一定的降压作用,为医疗机构制剂的备案提供了药学基础。

关键词: 杜钩平肝颗粒制备工艺质量标准药效学降压作用

DOI：10.13748/j.cnki.issn1007-7693.20230761

分类号:

基金项目:四川省中医药管理局科技产业创新团队专项（编号：2022C007）；西南医科大学附属中医医院自然科学研究基金：杜钩平肝颗粒防治高血压的制剂开发及作用机制研究

Study on Preparation and Pharmacodynamics of Duguopingan Granules

Ren gui lin¹, Pu Qingrong¹, Du Shijing², Tan Zhenghuai², Zhao Jian¹, Huang Rui¹, Luo Qun¹, Xie Chunguang³, Yang Sijin¹

1.The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University;2.Sichuan College of Traditional Chinese Medicine;3.Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Abstract:

Objective: To study the preparation process, quality standards, and preliminary pharmacodynamics of Dugoupinggan Granules, providing a basis for the preparation of medical institutions. Methods: The orthogonal experimental method was used to study the water extraction process, and the optimal water extraction process was selected based on the extraction rate and the content of puerarin. The quality standard of Duguopingan Granules was studied by TLC and HPLC. To study the preventive effect of Dugoupinggan Granule on L-NAME induced hypertension in rats. Results: The optimal extraction process for Dugoupinggan Granules is: 10 times the amount of water, soaking for 1 hour, decocting for 1.5 hours, and decocting for 3 times. The quality standard uses puerarin as the content determination index, and berberine hydrochloride, achyranthes bidentata, and stachydrine hydrochloride as the identification index. The pharmacodynamic test results showed that the low dose group of Dugoupinggan Granule could reduce systolic blood pressure and mean arterial pressure in rats, while the high dose group of Dugoupinggan Granule could reduce systolic blood pressure in rats. Conclusion: The preparation process of Dugoupinggan Granules is stable and feasible, and has a certain antihypertensive effect, providing a pharmaceutical basis for the filing of preparations in medical institutions.

Key words: Dugoupinggan Granules Preparation process Quality standards Pharmacodynamics Hypotensive effect