| 引用本文: | 鲍晓虹,叶田园,程肖蕊.GABA能神经传递在焦虑症中的作用及相关动物模型的研究进展[J].中国现代应用药学,2024,41(16):95-104. |
| BAO Xiaohong,YE Tianyuan,CHENG Xiaorui.The role of GABA signaling pathway in anxiety disorder and related models: A Review[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(16):95-104. |
|
| 摘要: |
| 焦虑症往往伴随着神经递质浓度的异常变化，GABA作为主要的抑制性神经递质，在焦虑症发病机制中发挥重要作用，治疗焦虑症的药物主要靶点涉及GABA受体、谷氨酸脱羧酶和GABA转运体，本文系统综述GABA能神经传递在焦虑症发病机制中的作用，并介绍基于GABA能神经传递的焦虑症动物模型的最新研究进展，为进一步深入揭示焦虑症发病机制和新药研发提供借鉴。 |
| 关键词: 焦虑症 GABA能神经传递 GABA受体 GABA转运体 谷氨酸脱羧酶 |
| DOI：10.13748/j.cnki.issn1007-7693.20224173 |
| 分类号: |
| 基金项目:西藏自治区科技计划重点研发计划（XZ202201ZY0026G）；中央引导地方科技发展专项资金项目（YDZX2023003）；山东中医药大学大学生研究训练计划项目（S202210441014） |
|
| The role of GABA signaling pathway in anxiety disorder and related models: A Review |
|
BAO Xiaohong, YE Tianyuan, CHENG Xiaorui
|
|
Shangdong University of Chinese Medicine,Chinese Medicine Innovation Research Institute
|
| Abstract: |
| Anxiety disorders are often accompanied by abnormal changes of the neurotransmitters concentration. GABA, the main inhibitory neurotransmitter, plays an important role in the pathogenesis of anxiety disorders. Main targets of drugs for the treatment of anxiety disorders involve GABA receptors, glutamate decarboxylase and GABA transporters. In addition, the latest research progress of animal models of anxiety based on GABAergic neurotransmission is introduced, which provides a reference for further revealing the pathogenesis of anxiety and the development of new medicine. |
| Key words: Anxiety disorders GABAergic neurotransmission GABA receptors GABA transporters Glutamic acid decarboxylase |
