| 引用本文: | 张娟,白庆云,田丽莉.水飞蓟素防治实验性肝病的作用及相关临床应用的研究进展[J].中国现代应用药学,2023,40(19):2745-2753. |
| ZHANG Juan,BAI Qingyun,TIAN Lili.Research Progress on the Effects of Silymarin Against Experimental Liver Diseases and Related Clinical Applications[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(19):2745-2753. |
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| 摘要: |
| 水飞蓟素是一种黄酮类化合物，具有清除活性氧、抗脂质过氧化、抗炎、抗肿瘤等多种药理作用。笔者通过查阅大量相关文献，发现水飞蓟素对各种肝病均具有较好的防治作用。随着基础研究的深入，发现水飞蓟素还可以促进肝细胞的修复与再生，与抗病毒药物及其他护肝药物联用时能更显著地降低血清转氨酶水平及改善肝纤维化，具有安全性高及耐受性好的优点。本文主要对水飞蓟素对不同肝病的防治作用、作用机制及其临床应用现状进行综述，以期为水飞蓟素在防治肝病方面的深入研究、药物开发和临床应用等方面提供参考。 |
| 关键词: 水飞蓟素 肝病 保肝作用 机制 临床应用 |
| DOI：10.13748/j.cnki.issn1007-7693.20222450 |
| 分类号:R969.3 |
| 基金项目:国家自然科学基金项目(81960748) |
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| Research Progress on the Effects of Silymarin Against Experimental Liver Diseases and Related Clinical Applications |
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ZHANG Juan1, BAI Qingyun1, TIAN Lili2
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1.Jiangxi Key Laboratory of Active Ingredients Research of Natural Drug, College of Chemistry and Bioengineering, Yichun University, Yichun 336000, China;2.TCM Dispensary, Pharmacy of Zhejiang Hospital, Hangzhou 310013, China
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| Abstract: |
| Silymarin is a kind of flavonoid compound with various pharmacological effects such as scavenging reactive oxygen species, anti-lipid peroxidation, anti-inflammation and anti-tumor. By reviewing a large number of related literature, found that silymarin has a better preventive and curative effect on various liver diseases. With the deepening of basic research, silymarin can also promote the repair and regeneration of hepatocytes, and when used in combination with antiviral drugs and other hepatoprotective drugs, it can significantly reduce serum aminotransferase levels and improve hepatic fibrosis, and it has the advantages of high safety and good tolerability. In this paper, the preventive and curative effects of silymarin on different liver diseases, its mechanism of action and its clinical application are summarized, with a view to providing reference for in-depth research, drug development and clinical application of silymarin in the prevention and treatment of liver diseases. |
| Key words: silymarin liver disease hepatoprotective effect mechanism clinical application |
