| 引用本文: | 周琴,曾佳,刘志丹,王计童,张裕,赵帆,王佳苗,刘敏臣,杜若飞.蜂毒肽在治疗炎性疾病中的研究进展[J].中国现代应用药学,2023,40(9):1270-1277. |
| ZHOU Qin,ZENG Jia,LIU Zhidan,WANG Jitong,ZHANG Yu,ZHAO Fan,WANG Jiamiao,LIU Minchen,DU Ruofei.Research Progress in the Treatment of Inflammatory Diseases with Melittin[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(9):1270-1277. |
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| 蜂毒肽在治疗炎性疾病中的研究进展 |
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周琴1, 曾佳2, 刘志丹3, 王计童1, 张裕1, 赵帆1, 王佳苗1, 刘敏臣1, 杜若飞1
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1.上海中医药大学, 上海 201203;2.上海市生物医药技术研究院, 国家卫生健康委员会计划生育药具重点实验室, 上海生殖健康药具工程技术研究中心, 上海 200032;3.上海市宝山区中西医结合医院康复科, 上海 201999
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| 摘要: |
| 炎性疾病是指因过度炎症反应所引发的或伴有炎症并发症的一类可影响人类健康的病症。目前临床上可通过抑制炎症反应达到治疗炎性疾病的目的,而常用的抗炎药虽然疗效明确,但都存在明显的不良反应,易给机体造成二次伤害,故抗炎新药亟待开发。蜂毒肽是从蜂毒中分离出的主要有效成分,具有较强的抗炎活性,其可通过介导炎症通路信号传递、抑制炎症细胞活性及炎症介质分泌等途径治疗多种炎性疾病,且疗效较好,具有较为广阔的临床应用前景。本文主要对蜂毒肽在治疗不同炎性疾病中的作用特点、蜂毒肽主要不良反应及应对策略进行了总结,以为后期蜂毒肽抗炎应用的临床开发提供参考。 |
| 关键词: 蜂毒肽 炎症 抗炎机制 不良反应 应对策略 |
| DOI：10.13748/j.cnki.issn1007-7693.20222292 |
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| 基金项目:国家自然科学基金项目(82174481)；上海市人才发展资金资助计划项目(2020086)；上海市宝山区中西医结合医院院级重点专科培育项目(BSYYZDZK-2019-04) |
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| Research Progress in the Treatment of Inflammatory Diseases with Melittin |
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ZHOU Qin1, ZENG Jia2, LIU Zhidan3, WANG Jitong1, ZHANG Yu1, ZHAO Fan1, WANG Jiamiao1, LIU Minchen1, DU Ruofei1
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1.Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2.Shanghai Institute for Biomedical and Pharmaceutical Technologies, NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai 200032, China;3.Department of Rehabilitation, Shanghai Baoshan District Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai 201999, China
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| Abstract: |
| Inflammatory disease is a kind of disease caused by excessive inflammatory reaction or accompanied by inflammatory complications that can affect human health. At present, inflammatory diseases can be treated clinically by inhibiting the inflammatory reaction. Although the commonly used anti-inflammatory drugs have clear efficacy, they all have obvious adverse reactions, which are easy to cause secondary damage to the body. Therefore, new anti-inflammatory drugs are urgently needed to be developed. Melittin is the main active ingredient isolated from bee venom, which has strong anti-inflammatory activity. It can treat a variety of inflammatory diseases by mediating the signal transmission of inflammatory pathway, inhibiting the activity of inflammatory cells and secretion of inflammatory mediators, and has a good curative effect, and has a broad clinical application prospect. In this paper, the effects and characteristics of melittin in the treatment of different inflammatory diseases, the main adverse reactions of melittin and coping strategies are summarized, so as to provide reference for the clinical development of anti-inflammatory application of melittin. |
| Key words: melittin inflammatory diseases anti-inflammatory mechanisms adverse reactions coping strategies |
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