| 引用本文: | 黄柯婷,王志旺,梁可克,席建宏,李济阳,杜玥,庞亚蓉.IL-13激活杯状细胞参与哮喘气道黏液高分泌的研究新进展[J].中国现代应用药学,2023,40(10):1416-1421. |
| HUANG Keting,WANG Zhiwang,LIANG Keke,XI Jianhong,LI Jiyang,DU Yue,PANG Yarong.New Research Progress of IL-13 Activating the Goblet Cell Involved in Mucus Hypersecretion of Asthma[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(10):1416-1421. |
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| 摘要: |
| 支气管哮喘(简称"哮喘")是一种气道炎症性疾病,炎症、气道重塑等多种因素引起的气道黏液高分泌是哮喘的主要病理特征,而杯状细胞激活并分泌黏蛋白5ac是哮喘黏液高分泌的关键环节,主要来源于Th2细胞的白介素-13 (interleukin-13,IL-13)通过多种信号途径激活杯状细胞并参与哮喘气道黏液高分泌过程。本文对近5年来IL-13激活杯状细胞参与哮喘气道黏液高分泌的研究进行综述,以期为哮喘以及其他呼吸系统疾病气道黏液高分泌的实验研究与新药开发提供理论依据。 |
| 关键词: 支气管哮喘 黏液高分泌 白介素-13 杯状细胞 黏蛋白5ac 信号通路 |
| DOI：10.13748/j.cnki.issn1007-7693.20221880 |
| 分类号: |
| 基金项目:国家自然科学基金项目(82260852，81460668)；甘肃省自然科学基金项目(20JR5RA183，1606RJZA011，1310RJZA086) |
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| New Research Progress of IL-13 Activating the Goblet Cell Involved in Mucus Hypersecretion of Asthma |
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HUANG Keting, WANG Zhiwang, LIANG Keke, XI Jianhong, LI Jiyang, DU Yue, PANG Yarong
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College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China
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| Abstract: |
| Bronchial asthma is an inflammatory disease of airway, and airway mucus hypersecretion caused by inflammation airway remodeling and other factors is the main pathological features of asthma. Activating goblet cells and secreting muc5ac are the key link of mucus hypersecretion in asthma. Interleukin-13(IL-13), mainly derived from Th2 cells, activates goblet cells through various signaling pathways and participates in the process of airway mucus hypersecretion in asthma. This study reviews IL-13 activated goblet cells participating in airway mucus hypersecretion in asthma in recent 5 years in order to provide theoretical basis for clinical treatment and new drug research of airway mucus hypersecretion in asthma and other respiratory diseases. |
| Key words: bronchial asthma mucus hypersecretion interleukin-13(IL-13) goblet cells mucin 5ac(Muc5ac) signaling pathway |
