| 引用本文: | 王雅楠,屈莲平,张治宽,曹阳君,石彩冬,张小凤,高峰.黄芪多糖在肿瘤免疫治疗中的研究进展[J].中国现代应用药学,2023,40(24):3452-3458. |
| WANG Yanan,QU Lianping,ZHANG Zhikuan,CAO Yangjun,SHI Caidong,ZHANG Xiaofeng,GAO Feng.Research Progress of Astragalus Polysaccharide in Tumor Immunotherapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(24):3452-3458. |
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| 黄芪多糖在肿瘤免疫治疗中的研究进展 |
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王雅楠1,2, 屈莲平2, 张治宽3, 曹阳君2, 石彩冬2, 张小凤2, 高峰1
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1.中国人民解放军联勤保障部队第九四〇医院结直肠肛门外科, 兰州 730050;2.甘肃中医药大学中医临床学院, 兰州 730000;3.甘肃省干细胞与基因药物重点实验室, 兰州 730050
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| 摘要: |
| 黄芪多糖（astragalus polysaccharides，APS）作为中国传统补气名药黄芪的主要活性成分之一，在调节免疫、抗氧化等方面具有良好的药理作用。近年来，随着PD-1/PD-L1抑制剂及抗CTLA-4药物在肿瘤治疗方面取得的成功，免疫治疗真正成为临床抗肿瘤的主要治疗方式之一。本文针对肿瘤免疫逃逸和肿瘤微环境改变的特性，挖掘APS作为抗肿瘤辅助用药的临床潜力，归纳了APS在抑制肿瘤免疫逃逸、调节肿瘤微环境、改善免疫功能等方面的作用及其机制。总结分析APS对各种肿瘤的免疫调控作用，以期为APS用作抗肿瘤辅助性药物提供客观依据。 |
| 关键词: 黄芪多糖 免疫治疗 免疫逃逸 肿瘤微环境 |
| DOI：10.13748/j.cnki.issn1007-7693.20221747 |
| 分类号:R285.5 |
| 基金项目:甘肃省科技计划项目（20YF8FA098） |
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| Research Progress of Astragalus Polysaccharide in Tumor Immunotherapy |
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WANG Yanan1,2, QU Lianping2, ZHANG Zhikuan3, CAO Yangjun2, SHI Caidong2, ZHANG Xiaofeng2, GAO Feng1
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1.Department of Colorectal & Anal Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China;2.Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;3.Key Laboratory of Stem Cells and Gene Drugs of Gansu Province, Lanzhou 730050, China
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| Abstract: |
| Astragalus polysaccharides(APS), as one of the main active components of Astragali Radix, a traditional famous tonic drug in China, has good pharmacological effects in regulating immunity and anti-oxidation. In recent years, with the success of PD-1/PD-L1 inhibitors and anti-CTLA-4 drugs in cancer treatment, immunotherapy has truly become one of the main clinical anti-tumor treatment methods. Aiming at the characteristics of tumor immune escape and tumor microenvironment change, this paper explores the clinical potential of APS as an anti-tumor adjuvant drug, and summarizes the role and mechanism of APS in inhibiting tumor immune escape, regulating tumor microenvironment, and improving immune function. To summarize and analyze the immune regulation of APS on various tumors in order to provide an objective basis for APS as a clinical anti-tumor adjuvant drug. |
| Key words: astragalus polysaccharides immunotherapy immune escape tumor microenvironment |
