| 引用本文: | 蔡锦云,钟海艺*,李培源*.姜黄素纳米凝胶的制备及其应用研究进展[J].中国现代应用药学,2023,40(4):562-568. |
| CAI Jinyun,ZHONG Haiyi*,LI Peiyuan*.Research Progress on the Preparation and Application of Curcumin Nanogel[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(4):562-568. |
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| 摘要: |
| 姜黄素是从姜黄根茎中提取分离得到的黄色多酚类化合物，具有抗肿瘤、抗炎、抗菌、抗氧化等广泛的药理活性。但由于其稳定性、水溶性差，生物利用度低等缺点严重地限制了姜黄素的治疗应用。纳米凝胶在改善姜黄素的溶解度、生物相容性、稳定性、靶向性和治疗效果方面均表现出良好的潜力。本文对姜黄素纳米凝胶的制备方法及其在肿瘤防治、创面治愈、炎症治疗和眼部给药等领域的应用进行综述，为姜黄素的进一步临床研究和应用开发提供文献参考。 |
| 关键词: 姜黄素 纳米凝胶 应用 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2023.04.021 |
| 分类号:R944.9 |
| 基金项目:广西科技计划项目基地和人才专项(桂科AD20297008) |
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| Research Progress on the Preparation and Application of Curcumin Nanogel |
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CAI Jinyun, ZHONG Haiyi*, LI Peiyuan*
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College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China
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| Abstract: |
| Curcumin is a yellow polyphenol isolated from the rhizome of Curcuma longa L., has a wide range of pharmacological activities including anticancer, anti-inflammatory, antibacterial and antioxidant. However, its poor stability, poor water solubility and low bioavailability seriously limit the therapeutic applications of curcumin. Nanogels have demonstrated promising potential for improving the solubility, biocompatibility, stability, targeting and therapeutic efficacy of curcumin. In this paper, the preparation of curcumin nanogels and their applications in cancer therapy, wound healing, inflammation treatment and ophthalmic delivery are reviewed to provide a literature reference for the further clinical research and application development of curcumin. |
| Key words: curcumin nanogel application research progress |
