Omega-3多不饱和脂肪酸在肺部疾病中的作用研究进展

李经历; 李恩力; 张春意; 孙健<sup>*</sup>

引用本文:	李经历,李恩力,张春意,孙健.Omega-3多不饱和脂肪酸在肺部疾病中的作用研究进展[J].中国现代应用药学,2023,40(7):989-993.
	LI Jingli,LI Enli,ZHANG Chunyi,SUN Jian.Research Progress in Omega-3 in Polyunsaturated Fatty Acids in Pulmonary Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(7):989-993.

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Omega-3多不饱和脂肪酸在肺部疾病中的作用研究进展
李经历¹, 李恩力², 张春意¹, 孙健¹
1.绍兴市人民医院呼吸与危重症医学科, 浙江绍兴 312000;2.宁波大学医学院, 浙江宁波 315000

摘要:

Omega-3多不饱和脂肪酸(omega-3 polyunsaturated fatty acids,ω-3 PUFA)的有效成分包括二十碳五烯酸和二十二碳六烯酸,具有抗炎、抗氧化和免疫调节的作用。研究表明,饮食中补充ω-3 PUFA对急性肺损伤/急性呼吸窘迫综合征、哮喘、慢性阻塞性肺疾病和肺癌等多种肺部疾病具有预防和治疗作用。因此,本文就ω-3 PUFA在肺部疾病中的作用及其机制的最新研究进展进行综述,以期为ω-3 PUFA在呼吸系统的广泛应用提供参考。

关键词: Omega-3多不饱和脂肪酸肺部疾病急性肺损伤哮喘

DOI：10.13748/j.cnki.issn1007-7693.20220926

分类号:R563

基金项目:浙江省医药卫生科技计划项目(2022RC272)

Research Progress in Omega-3 in Polyunsaturated Fatty Acids in Pulmonary Diseases

LI Jingli¹, LI Enli², ZHANG Chunyi¹, SUN Jian¹

1.Department of Respiratory and Critical Care Medicine, Shaoxing People's Hospital, Shaoxing 312000, China;2.Ningbo University School of Medicine, Ningbo 315000, China

Abstract:

Omega-3 polyunsaturated fatty acids(ω-3 PUFA) have anti-inflammatory, antioxidant and immunomodulatory effects, the active ingredients of which include eicosapentaenoic acid and docosahexaenoic acid. Studies have shown that supplementing the diet with ω-3 PUFA has preventive and therapeutic effects on a variety of lung diseases, including acute lung injury/acute respiratory distress syndrome, asthma, chronic obstructive pulmonary disease, and lung cancer. Therefore, this article reviews the latest research progress on the effects and mechanisms of ω-3 PUFA on lung diseases, in order to provide a reference for the treatment of respiratory system diseases.

Key words: omega-3 polyunsaturated fatty acids lung diseases acute lung injury asthma