| 引用本文: | 王永刚,关子昂,于鑑衡,王永耀,孙小涵,王珏,刘金晶,于润乔,王红日.热熔胶基质和热熔胶贴膏制备技术的应用分析[J].中国现代应用药学,2022,39(8):1088-1094. |
| WANG Yonggang,GUAN Zi’ang,YU Jianheng,WANG Yongyao,SUN Xiaohan,WANG Jue,LIU Jinjing,YU Runqiao,WANG Hongri.Application Analysis of Hot-melt Pressure-sensitive Adhesive Matrix and Preparation Technology of Hot-melt Pressure-sensitive Adhesive Plaster[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(8):1088-1094. |
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| 热熔胶基质和热熔胶贴膏制备技术的应用分析 |
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王永刚1,2,3, 关子昂1, 于鑑衡2, 王永耀3, 孙小涵1, 王珏1, 刘金晶1, 于润乔2, 王红日3
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1.沈阳永晟康泰医药科技有限公司, 沈阳 110101;2.长春邦尔生物工程有限公司, 长春 130507;3.沈阳永刚胶粘制品厂, 沈阳 110101
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| 摘要: |
| 目的 探讨热熔胶贴膏基质及热熔胶贴膏制备技术。方法 通过不同配方分析出合理的热熔胶基质组分；结合设备论述热熔胶贴膏生产工艺，探讨热熔胶贴膏生产操作要点，分析生产热熔胶贴膏的优点、存在问题与解决方法，展望热熔胶贴膏的发展前景。结果 由符合中国药典2020年版制剂通则的聚合基体、增塑剂、增黏剂组成的热熔载体胶，比较适合作为热熔胶贴膏剂的基质；混料和涂胶是生产热熔胶贴膏的重点岗位，低温操作与合理的加药顺序能够减少药物有效成分损失，透气性好的骨架材料和小分子量高相容性的药物有利于药物释放，亲水性材料制成的热熔胶基质能够改善其耐汗性。结论 生产热熔胶贴膏与天然橡胶贴膏相比，产品外型美观，贴用舒适，无刺激性、弱过敏，设备投资少，工艺简单，生产效率高，安全，环保。以热熔胶作基质代替天然橡胶基质生产贴膏剂是未来发展方向，热熔胶贴膏有很好的发展前景。 |
| 关键词: 热熔胶 贴膏剂 生产工艺 基质 橡胶贴膏 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.08.013 |
| 分类号:R943 |
| 基金项目: |
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| Application Analysis of Hot-melt Pressure-sensitive Adhesive Matrix and Preparation Technology of Hot-melt Pressure-sensitive Adhesive Plaster |
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WANG Yonggang1,2,3, GUAN Zi’ang1, YU Jianheng2, WANG Yongyao3, SUN Xiaohan1, WANG Jue1, LIU Jinjing1, YU Runqiao2, WANG Hongri3
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1.Shenyang Yongsheng Kangtai Pharmaceuticals and Medical Technology Co., Ltd., Shenyang 110101, China;2.Changchun Banger Bioengineering Co., Ltd., Changchun 130507, China;3.Shenyang Yonggang Adhesive Products Factory, Shenyang 110101, China
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| Abstract: |
| OBJECTIVE To discuss hot-melt pressure-sensitive adhesive plaster matrix and the preparation technology of hot-melt pressure-sensitive adhesive plaster. METHODS The reasonable hot-melt pressure-sensitive adhesive matrix components were analyzed by different formulation. Combined with the equipment, the production process and the key points of production operation of hot-melt pressure-sensitive adhesive plaster were discussed. The advantages, existing problems and solutions of hot-melt pressure-sensitive adhesive paste production were analyzed, and the development of hot-melt pressure-sensitive adhesive plaster was also prospected. RESULTS The hot-melt pressure-sensitive adhesive, which was composed of polymer matrix, plasticizer and tackifier according to the general provisions of the 2020 edition of the "Chinese Pharmacopoeia", was more suitable as a matrix for hot-melt pressure-sensitive adhesive plaster. Mixing and coating were the key positions in the production of hot-melt pressure-sensitive adhesive plaster. Low temperature operation and reasonable dosing sequence could reduce the loss of active ingredients of drugs. Good gas permeability framework materials and small molecular weight and highly compatible drugs were conducive to drug release. The hot-melt pressure-sensitive adhesive matrix made of hydrophilic material can improve its sweat resistance. CONCLUSIONS Compared with natural rubber plaster, the production of hot-melt pressure-sensitive adhesive plaster has beautiful appearance, comfortable application, non-biological irritant, less allergy, less equipment investment, simple process, high production efficiency, safety and environmental protection. In the future, natural rubber will be replaced by hot-melt pressure-sensitive adhesive as the matrix of plaster, and the hot-melt pressure-sensitive adhesive plaster has a better development prospect. |
| Key words: hot-melt pressure-sensitive adhesive plaster production process matrix rubber adhesive plaster |
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