非抗感染目的长程应用阿奇霉素的安全性研究现状

孟凡堰; 梁虹艺; 季波

引用本文:	孟凡堰,梁虹艺,季波.非抗感染目的长程应用阿奇霉素的安全性研究现状[J].中国现代应用药学,2022,39(20):2691-2696.
	MENG Fanyan,LIANG Hongyi,JI Bo.Research Status on Safety of Long-term Application of Azithromycin for Non-antibacterial Purposes[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(20):2691-2696.

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非抗感染目的长程应用阿奇霉素的安全性研究现状
孟凡堰¹, 梁虹艺², 季波²
1.贵州省安顺市人民医院药剂科, 贵州安顺 561000;2.中国人民解放军南部战区总医院临床药学科, 广州 510010

摘要:

阿奇霉素以往通常用于短程抗感染治疗，然而近年来发现它具有多方面的抗菌外效应，国外多个指南推荐用于哮喘、支气管扩张、慢性阻塞性肺疾病等呼吸道疾病的辅助治疗中。由于这种以非抗感染目的长程应用阿奇霉素的给药方式，具有用药疗程长、适用范围广等特点，其存在的潜在安全性问题(如细菌耐药性增加、心脏毒性、听力受损等)备受关注，也颇具争议。本文旨在阐述阿奇霉素在长期应用过程中涉及安全性方面的研究现状，以期客观和正确认识其潜在风险，为临床决策提供参考。

关键词: 阿奇霉素长程非抗菌效应安全性

DOI：10.13748/j.cnki.issn1007-7693.2022.20.018

分类号:R969.3

基金项目:安顺市科技计划项目(安市科社[2021]55号)；贵州省科技计划项目(黔科合基础-ZK[2021]一般557)

Research Status on Safety of Long-term Application of Azithromycin for Non-antibacterial Purposes

MENG Fanyan¹, LIANG Hongyi², JI Bo²

1.Department of Pharmacy, People's Hospital of Anshun City Guizhou Province, Anshun 561000, China;2.Department of Clinical Pharmacy, General Hospital of Southern Theatre Command, PLA, Guangzhou 510010, China

Abstract:

Azithromycin was usually used in short-term anti-infection therapy in the past. However, azithromycin has been found to have many non-antibacterial effects in recent years. Many foreign guidelines recommend it for the adjuvant treatment of respiratory diseases such as asthma, bronchiectasis and chronic obstructive pulmonary disease. Due to the long-term application of azithromycin for the purpose of non-antibacterial effects, it has the characteristics of long treatment course and wide application range. Therefore, its potential safety problems(such as increased bacterial drug resistance, cardiotoxicity, hearing loss, etc.) have attracted extensive attention and controversial. This paper aims to describe the research status of safety of azithromycin in the process of long-term application, in order to objectively and correctly understand its potential risks and provide help and reference for clinical decision-making.

Key words: azithromycin long-term non-antibacterial effect safety