| 引用本文: | 张尚祖,张利英,陈琰,刘永琦.细胞焦亡与肺癌研究进展[J].中国现代应用药学,2022,39(14):1901-1907. |
| ZHANG Shangzu,ZHANG Liying,CHEN Yan,LIU Yongqi.Advances in Research on Pyroptosis and Lung Cancer[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(14):1901-1907. |
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| 摘要: |
| 细胞焦亡是由炎症小体引发的细胞炎症性坏死形式，其特点是半胱氨酸蛋白酶介导促炎因子和 Gasdermin 家族蛋白活化，导致膜孔形成、细胞肿胀、质膜裂解、染色质碎裂和细胞内促炎内容物释放。炎症小体存在于多种肿瘤细胞，可以通过介导细胞焦亡影响肿瘤的增殖、侵袭和转移。研究发现细胞焦亡与肺癌发病、进展、预后及耐药的发生密切相关，归纳总结细胞焦亡的分子机制及其在肺癌治疗中的研究进展，有利于为肺癌的诊疗和新药研发提供新的依据。 |
| 关键词: 肺癌 细胞焦亡 分子机制 天然产物 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.14.018 |
| 分类号:R966 |
| 基金项目:国家自然科学基金项目(81973595，82004094)；甘肃省“双一流”科研重点项目(GSSYLXM-05) |
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| Advances in Research on Pyroptosis and Lung Cancer |
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ZHANG Shangzu1, ZHANG Liying1,2, CHEN Yan1, LIU Yongqi1,2
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1.Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;2.Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Lanzhou 730000, China
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| Abstract: |
| Pyroptosis is a form of inflammatory necrosis caused by inflammatory bodies. It is characterized by caspase mediated activation of inflammatory cytokines and Gasdermin family proteins, resulting in membrane pore formation, cell swelling, plasma membrane lysis, chromatin fragmentation and release of intracellular pro-inflammatory contents. Inflammatory corpuscles exist in a variety of tumor cells. Inflammatory corpuscles can affect tumor proliferation, invasion and metastasis by mediating cell death. It is found that cell death is closely related to the pathogenesis, progress, prognosis and drug resistance of lung cancer. Summarizing the molecular mechanism of cell death and its research progress in the treatment of lung cancer is helpful to provide a new basis for the diagnosis and treatment of lung cancer and the development of new drugs. |
| Key words: lung cancer pyroptosis molecular mechanism natural products |
