| 引用本文: | 史志恒,曾嘉琳,黄欣如,彭雨涵,苏薇薇,王永刚.槲皮素及其衍生物抗病毒活性研究进展[J].中国现代应用药学,2022,39(18):2412-2420. |
| SHI Zhiheng,ZENG Jialin,HUANG Xinru,PENG Yuhan,SU Weiwei,WANG Yonggang.Research Progress of Antiviral Activity of Quercetin and Its Derivatives[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(18):2412-2420. |
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| 摘要: |
| 槲皮素是一种天然黄酮类化合物，广泛存在于各种蔬菜、水果和中草药中。槲皮素及其衍生物具有抗氧化、抗菌、抗肿瘤、抗溃疡、神经保护和改善心脑血管疾病等功效。同时，槲皮素及其衍生物的广谱抗病毒活性已被各种科学研究充分证明，如抗SARS相关冠状病毒、抗甲型流感病毒、抗肝炎病毒、抗埃博拉病毒和抗疱疹病毒活性等。本文综述了近十年槲皮素及其衍生物在抗病毒方面的研究进展和作用机制，为其进一步的开发利用以及临床研究提供参考。 |
| 关键词: 槲皮素 衍生物 黄酮类化合物 抗病毒 作用机制 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.18.019 |
| 分类号:R285.5 |
| 基金项目:广东省热带亚热带植物资源重点实验室开放课题(2020PlantKF02);广州呼吸健康研究院开放课题(中国恒大集团资金资助)(2020GIRHHMS15) |
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| Research Progress of Antiviral Activity of Quercetin and Its Derivatives |
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SHI Zhiheng, ZENG Jialin, HUANG Xinru, PENG Yuhan, SU Weiwei, WANG Yonggang
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Guangdong Provincial Key Laboratory of Tropical and Subtropical Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
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| Abstract: |
| Quercetin is a natural flavonoid compound,which is widely found in various vegetables,fruits and Chinese herbal medicines.Quercetin and its derivatives are effective in anti-oxidation,anti-bacterial,anti-cancer,anti-ulcer,neuroprotection and improvement of cardiovascular and cerebrovascular diseases.The broad-spectrum antiviral activities of quercetin and its derivatives have been fully proved by various scientific researches,such as anti-SARS-related coronavirus,anti-influenza A virus,anti-hepatitis virus,anti-Ebola virus and anti-herpes virus activities.This article reviews the research progress and mechanism of antiviral effects of quercetin and its derivatives reported in the past ten years,laying the foundation for its further development and utilization and clinical research. |
| Key words: quercetin derivatives flavonoids antiviral mechanism |
