| 引用本文: | 杨诗宇,宋基正,杨山景,李杰雨,姜海梅,隋芳茜,李凌军.芦丁药理作用与新剂型的研究进展[J].中国现代应用药学,2022,39(10):1360-1370. |
| YANG Shi-yu,SONG Ji-zheng,YANG Shan-jing,LI Jie-yu,JIANG Hai-mei,SUI Fang-qian,LI Ling-jun.Research Progress on Pharmacological Action and New Dosage Forms of Rutin[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(10):1360-1370. |
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| 摘要: |
| 芦丁是一种天然的黄酮类化合物,在临床上常被用于治疗心血管类疾病,具有抗心肌损伤、抗炎、抗氧化、抗细胞凋亡、抗菌、抗病毒等药理活性,不良反应小。芦丁是治疗多种疾病的潜力药物,但因水溶性差和渗透性差导致口服生物利用度低,而在临床应用中受限。为了提高芦丁的水溶性和渗透性,改善生物利用度,多种新型芦丁制剂被研究。本文查阅国内外相关文献和报道,对芦丁的基本性质、药理作用、生物利用度和药动学研究现状进行归纳,并总结了芦丁的新剂型研究,阐述不同剂型对芦丁生物利用度和药动学参数的影响,为研发芦丁相关新药提供参考。 |
| 关键词: 芦丁 药理作用 新型制剂 生物利用度 药动学 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.10.016 |
| 分类号:R965 |
| 基金项目:“重大新药创制”国家科技重大专项(2017ZX09301064) |
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| Research Progress on Pharmacological Action and New Dosage Forms of Rutin |
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YANG Shi-yu, SONG Ji-zheng, YANG Shan-jing, LI Jie-yu, JIANG Hai-mei, SUI Fang-qian, LI Ling-jun
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College of Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China
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| Abstract: |
| Rutin is a kind of natural flavonoids, which is often used in the treatment of cardiovascular diseases in clinic. It has pharmacological activities such as anti-myocardial injury, anti-inflammatory, antioxidant, anti-apoptosis, antibacterial,antiviral and other pharmacological activities, with little adverse reactions. Rutin is a potential drug for the treatment of many diseases, but its oral bioavailability is low due to poor water solubility and poor permeability, which is limited in clinical application. In order to improve the water solubility and permeability of rutin, improve bioavailability, a variety of new rutin preparations have been studied. Referring to the relevant literature and reports at home and abroad, the paper summarize the basic properties, pharmacological action, bioavailability and pharmacokinetics of rutin, and summarize the study of new dosage forms of rutin. In this paper, the effects of different dosage forms on the bioavailability and pharmacokinetic parameters of rutin are reviewed in order to provide reference for the development of new rutin drugs. |
| Key words: rutin pharmacological activities new dosage form bioavailability pharmacokinetics |
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